DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a6

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_006255560.1	Gene:	Slc7a6 / 307811	RGDID:	1309193	Length:	528	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	193/500 - (38%)
Similarity:	305/500 - (61%)	Gaps:	33/500 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PTKT------TSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFS 88
            ||.|      .:..|:..:.|..::|  :|||                      :.|::.:.|.:
  Rat    22 PTPTYHLLPKANQHTVKEDASSPSQG--SPET----------------------MQLKKEISLLN 62

  Fly    89 GVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAY 153
            ||:|:||.||||||||||.|:|..|.|.|:|.::|...|:.|::|||.||||||..|.|||.:||
  Rat    63 GVSLVVGNMIGSGIFVSPKGVLKYTASYGLSLVVWAIGGLFSVVGALCYAELGTTITKSGASYAY 127

  Fly   154 FMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILF 218
            .::|:|...||:..|||.|:::|:..|||.::||.|.::.....||||....:::|...:.::.|
  Rat   128 ILEAFGGFIAFIRLWVSLLIVEPTSQAIIAITFANYIIKPSFPTCDPPYVACRLLAAACVCLLTF 192

  Fly   219 VNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGL 283
            |||..|..|..||:.||.||::|::.:|..|..||.||:|:|..:||.|...|||.::.|.|:.|
  Rat   193 VNCAYVKWGTRVQDTFTYAKVLALIAIIIMGLVKLCQGHTEHFQDAFKGSSWNVGDLSLALYSAL 257

  Fly   284 WAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFG 348
            ::|.||:.||:||||||||.:|||.:|.|.:|:|||.|.|.|::|...::.|::.:|:||||||.
  Rat   258 FSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNIQDVHKSDAVAVTFA 322

  Fly   349 NRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHS 413
            ::..|..:|.:|::|.:|.||..|.::||:.||.|..||||||.::||.:|:.|.||.|.|:|:.
  Rat   323 DQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPNLLSMIHIERFTPVPALLFNC 387

  Fly   414 LIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYL 478
            .:....::...:..||::|||:.|.|.|.:::..:.:|:.:|::|||.|:.:..|:|..:.|::|
  Rat   388 TMTLIYLVVKDVFLLINYFSFSYWFFVGLSVVGQLYLRWKEPDWPRPLKLSLFFPIVFCICSLFL 452

  Fly   479 VAAPIFETPRVEYLYALLFIFAGLIFYVPFVKL--GMTPRFMNKV 521
            ||.|:| :..:..|..:....:|:..|...|.|  ...|.|:.||
  Rat   453 VAVPLF-SDTINSLIGIGIALSGVPVYFMGVYLPEARRPLFIRKV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	186/470 (40%)
Slc7a6	XP_006255560.1	2A0308	30..514	CDD:273332	189/491 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730