DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a15

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001100184.1	Gene:	Slc7a15 / 298873	RGDID:	1560726	Length:	488	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	217/492 - (44%)
Similarity:	314/492 - (63%)	Gaps:	19/492 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLL 110
            |::.||..|..|...|                :.::|.:||:|.|::..|.|||||||:||.|:|
  Rat     9 GSDKPEGQEQGSGAAG----------------LTMKREIGLWSAVSMTAGCMIGSGIFMSPQGVL 57

  Fly   111 VRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLK 175
            |..||.|.|.|||..||:|:|||||.|||||::...||.|:||.:.|:|..||||..::..||.:
  Rat    58 VYIGSPGASLIIWATCGLLALLGALCYAELGSLVPESGGEYAYILRAFGSLPAFLVIYIIVLVGR 122

  Fly   176 PSQMAIICLSFAQYAVEAFVTECDP-PRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKL 239
            |:.:..:.||||:||:..|...|.. |:.:||:||...|:::|.:|.:|..:...:.||.|||||
  Rat   123 PAAITAVSLSFAEYALAPFYPGCSSVPQVIVKIVACSCILVLLLINFWSSRMSTVLMNVCTAAKL 187

  Fly   240 VAVVVVICGGAWKLMQGN--TQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNP 302
            .:::|::.|||..|.||.  |:.|..||:......|.|..|||.|||::|||:|:|.|.||||||
  Rat   188 FSLLVIVVGGAVGLAQGRIPTESLLFAFHNTTQQAGRIGMAFYQGLWSFDGWSNINTVIEEIKNP 252

  Fly   303 SKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTIST 367
            .:||..:::|.|||||:.|.|:|||||..|||.|::.|:|:|||:||::||:.|||:||:|.:||
  Rat   253 KQNLVWAVVIAIPLVTILYVLVNISYLLVMSPSEILTSDAIAVTWGNQVLGSWAWLVPLAVALST 317

  Fly   368 FGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFF 432
            ||:.||..|:..|:|:||:||||:..::|.:||.||||||.|||.:.:|..:|:.|...:.::..
  Rat   318 FGAVNGGFFSGSRVCYAAAREGHMPQLMSMIHVHRLTPAPALIFTTAVALLLVIPGNFSTFVNLL 382

  Fly   433 SFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLF 497
            ||.:|:.||.....|:.:|....|....||||..|||::|::|:|||.|||.:.|::|:||..||
  Rat   383 SFLSWLTYGTTFACLLYLRIKTRNLHHTYKVPTFIPVIMLLVSLYLVLAPIIDHPQMEFLYIFLF 447

  Fly   498 IFAGLIFYVPFVKLGMTPRFMNKVTLFFQLLLEVVPT 534
            :..|...|..........:.:...|:..||||||.||
  Rat   448 VLTGFPVYFLLFHFQCQSKCVQTATMHLQLLLEVAPT 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	211/481 (44%)
Slc7a15	NP_001100184.1	2A0308	4..481	CDD:273332	213/487 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D385385at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.890