DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a3

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_058913.1	Gene:	Slc7a3 / 29485	RGDID:	68342	Length:	619	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	107/433 - (24%)
Similarity:	180/433 - (41%)	Gaps:	62/433 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 RKPLERN-GSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFII-WLAC 126
            |:.||.. |.|:     |.|.|.....|||.||:.:|:|::|....  |.....|.|.:| :|..
  Rat    16 RRLLELGMGETR-----LARCLSTLDLVALGVGSTLGAGVYVLAGE--VAKEKAGPSIVICFLVA 73

  Fly   127 GVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSW--VSTLVLKPSQMAIICLSFAQY 189
            .:.|:|..|.|||.|.....||:.:.|.....|...||...|  :.:.|:..:.:|....|....
  Rat    74 ALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDN 138

  Fly   190 AVEAFVTE-------CDPPRGVVKMVALVAIVMILFVN---CYSVNLGMAVQNVFTAAKLVAVVV 244
            .:...:::       .:.|..:.:.....|:.::|.:.   ....|....|..|||...|:.:..
  Rat   139 LIGNHISQTLKGTILLNMPHVLAEYPDFFALALVLLLTGLLVLGANESGLVTKVFTGMNLLVLGF 203

  Fly   245 VICGG-------AWKLMQGN---TQHLSN--------AFNGPMP-----NVGAIATAFYTGLWAY 286
            ||..|       .|||.:.:   |...||        ...|.||     .:...||.||    |:
  Rat   204 VIISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFY----AF 264

  Fly   287 DGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEA---VAVTFG 348
            .|::.:....||.:||.:::|..|:|.:.:..|.|..:: |.|..|.|...::.|:   .|.|:.
  Rat   265 VGFDCIATTGEEAQNPQRSIPMGIVISLSICFLAYFGVS-SALTLMMPYYKLQPESPLPEAFTYV 328

  Fly   349 N----RILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGL 409
            .    |.|.|:..|..||.::.      |::|...|:.:|.:.:|.|..:|:.||....||....
  Rat   329 GWEPARYLVAIGSLCALSTSLL------GSMFPMPRVIYAMAEDGLLFRVLARVHNGTHTPIVAT 387

  Fly   410 IFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRY 452
            :...:||:.|.....:..|:|..|....:.|....:.::::||
  Rat   388 VVSGVIAAFMAFLFELTDLVDLMSIGTLLAYSLVSICVLILRY 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	107/433 (25%)
Slc7a3	NP_058913.1	2A0303	4..591	CDD:273330	107/433 (25%)
Slc7a3	NP_058913.1	AA_permease_C	<551..589	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010