DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbm and Slc7a11

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_036120.1	Gene:	Slc7a11 / 26570	MGIID:	1347355	Length:	502	Species:	Mus musculus

Alignment Length:	480	Identity:	192/480 - (40%)
Similarity:	297/480 - (61%)	Gaps:	4/480 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 TGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWL 124
            :||:....::....|..|| |::::.|..||::|:||:||||||:||.|:|..|||||:|.:.|.
Mouse    21 SGRLPSMGDQEPPGQEKVV-LKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWS 84

  Fly   125 ACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQY 189
            |||||||.|||:||||||....||..:.|.::.:||..||:..||..||::|...|:|.|:|.:|
Mouse    85 ACGVLSLFGALSYAELGTSIKKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRY 149

  Fly   190 AVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLM 254
            .:|.|..:|:.|...:|:|..|.|.:::.:|..||:....:|...|..||.|::::|..|..:|:
Mouse   150 ILEPFFIQCEIPELAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQLI 214

  Fly   255 QGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTL 319
            :|.|.|..:||:|...::..:..|||.|::||.||..||::|||:.||.|.:|.:|.|.:.::|:
Mouse   215 KGQTHHFKDAFSGRDTSLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAIITV 279

  Fly   320 CYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFA 384
            .|.|.|::|...:|.:|:::|.||||||..|:||..:..:|:.|.:|.|||.||.:||..||.:.
Mouse   280 GYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGGVFAVSRLFYV 344

  Fly   385 ASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIV 449
            |||||||.:|||.:||.:.||.|.:|....:...|:..|.:.||::|.||..|:|.|.|:..||.
Mouse   345 ASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMVMLFSGDLYSLLNFLSFARWLFMGLAVAGLIY 409

  Fly   450 MRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETP---RVEYLYALLFIFAGLIFYVPFVKL 511
            :||.:|:..||:|||:.||.:.....:::|...::..|   .|.:|..|..:.|..:|.|...|.
Mouse   410 LRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLITLTGVPAYYLFIVWDKKP 474

  Fly   512 GMTPRFMNKVTLFFQLLLEVVPTSS 536
            ....|..:::|...|::|||||..|
Mouse   475 KWFRRLSDRITRTLQIILEVVPEDS 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	188/474 (40%)
Slc7a11	NP_036120.1	2A0308	1..498	CDD:273332	191/477 (40%)
Slc7a11	NP_036120.1	SLC5-6-like_sbd	42..>291	CDD:294310	105/248 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820