Protein Alignment sbm and SLC7A11

DIOPT Version :10

• Sequence 1: NP_727785.1
• Gene: sbm / 32397
• FlyBaseID: FBgn0030574
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_011530104.1
• Gene: SLC7A11 / 23657
• HGNCID: 11059
• Length: 506
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 187/478 - (39%)
• Similarity: 291/478 - (60%)
• Gaps: 26/478 - (5%)

  Fly    63 MRKP----LERNGSTQNHV-----------------VHLERRLGLFSGVALIVGTMIGSGIFVSP 106
            :|||    :.:.|..|.:|                 |.|:|::.|..||::|:||:||:|||:||
Human     2 VRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISP 66

  Fly   107 SGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVST 171
            .|:|..|||||:|..||..||||||.|||:||||||....||..:.|.::.:||.|||:..||..
Human    67 KGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVEL 131

  Fly   172 LVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTA 236
            |:::|:..|:|.|:|.:|.:|.|..:|:.|...:|::..|.|.:::.:|..||:....:|...|.
Human   132 LIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTF 196

  Fly   237 AKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKN 301
            .||.|::::|..|..:|::|.||:..:||:|...::..:..|||.|::||.||..||:||||::|
Human   197 CKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVEN 261

  Fly   302 PSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTIS 366
            |.|.:|.:|.|.:.:||:.|.|.|::|...::.:|::.|.||||||..|:||..:..:|:.|.:|
Human   262 PEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALS 326

  Fly   367 TFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDF 431
            .|||.||.:||..||.:.|||||||.:|||.:|||:.||.|.:|....:...|:..|.:|||::|
Human   327 CFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNF 391

  Fly   432 FSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALL 496
            .||..|:|.|.|:..||.:||..|:..||:|||:.||.:.....:::||..::..|   :...:.
Human   392 LSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDP---FSTGIG 453

  Fly   497 FI--FAGLIFYVPFVKLGMTPRF 517
            |:  ..|:..|..|:.....||:
Human   454 FVITLTGVPAYYLFIIWDKKPRW 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	187/478 (39%)
SLC7A11	XP_011530104.1	2A0308	1..483	CDD:273332	187/478 (39%)