DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and SLC7A11

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_011530104.1	Gene:	SLC7A11 / 23657	HGNCID:	11059	Length:	506	Species:	Homo sapiens

Alignment Length:	478	Identity:	187/478 - (39%)
Similarity:	291/478 - (60%)	Gaps:	26/478 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 MRKP----LERNGSTQNHV-----------------VHLERRLGLFSGVALIVGTMIGSGIFVSP 106
            :|||    :.:.|..|.:|                 |.|:|::.|..||::|:||:||:|||:||
Human     2 VRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISP 66

  Fly   107 SGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVST 171
            .|:|..|||||:|..||..||||||.|||:||||||....||..:.|.::.:||.|||:..||..
Human    67 KGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVEL 131

  Fly   172 LVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTA 236
            |:::|:..|:|.|:|.:|.:|.|..:|:.|...:|::..|.|.:::.:|..||:....:|...|.
Human   132 LIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTF 196

  Fly   237 AKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKN 301
            .||.|::::|..|..:|::|.||:..:||:|...::..:..|||.|::||.||..||:||||::|
Human   197 CKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVEN 261

  Fly   302 PSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTIS 366
            |.|.:|.:|.|.:.:||:.|.|.|::|...::.:|::.|.||||||..|:||..:..:|:.|.:|
Human   262 PEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALS 326

  Fly   367 TFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDF 431
            .|||.||.:||..||.:.|||||||.:|||.:|||:.||.|.:|....:...|:..|.:|||::|
Human   327 CFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNF 391

  Fly   432 FSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALL 496
            .||..|:|.|.|:..||.:||..|:..||:|||:.||.:.....:::||..::..|   :...:.
Human   392 LSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDP---FSTGIG 453

  Fly   497 FI--FAGLIFYVPFVKLGMTPRF 517
            |:  ..|:..|..|:.....||:
Human   454 FVITLTGVPAYYLFIIWDKKPRW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	187/478 (39%)
SLC7A11	XP_011530104.1	2A0308	1..483	CDD:273332	187/478 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830