DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and SLC7A8

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_036376.2	Gene:	SLC7A8 / 23428	HGNCID:	11066	Length:	535	Species:	Homo sapiens

Alignment Length:	498	Identity:	198/498 - (39%)
Similarity:	301/498 - (60%)	Gaps:	32/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLL 110
            |.|...:||..|.|.|                |.|::.:||.|...:|||.:|||||||||.|:|
Human    18 GGESDASPEAGSGGGG----------------VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVL 66

  Fly   111 VRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLK 175
            ...||||::.|:|:..|.::::|||.|||||.....||.:::|..|.:|....||..|::.||:.
Human    67 ENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIY 131

  Fly   176 PSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLV 240
            |:..|:|.|:|:.|.::.....|.||...::::|.:.::::.:|||.||.....||::|||.||:
Human   132 PTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLL 196

  Fly   241 AVVVVICGGAWKLMQGNTQHL--SNAF-NGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNP 302
            |:.::|..|..::.:|....|  .||| |...|::|.:|.||..|.:||.|||.|||||||:.:|
Human   197 ALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDP 261

  Fly   303 SKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTIST 367
            .|||||:|.|.|||||..|...|::|:.||||||::.|.|||||||.::||.:||:||:||.:||
Human   262 YKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALST 326

  Fly   368 FGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFF 432
            ||..||:||.:.||.||.:|||||..:|:.:||:|.||.|.|:|..:....|::...:.:||::.
Human   327 FGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYV 391

  Fly   433 SFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLF 497
            .|..::|||..:...||:|:.||:.|||.|:.::.|::.|:...:|:...::..|.|..: .|..
Human   392 GFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGI-GLAI 455

  Fly   498 IFAGLIFYVPFVKLGM----TPR----FMNKVTLFFQLLLEVV 532
            :..|    ||...||:    .|:    |:..:||..|.:..||
Human   456 MLTG----VPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	194/489 (40%)
SLC7A8	NP_036376.2	2A0308	1..497	CDD:273332	198/498 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..535
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760