DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a7

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_030103562.1	Gene:	Slc7a7 / 20540	MGIID:	1337120	Length:	596	Species:	Mus musculus

Alignment Length:	479	Identity:	185/479 - (38%)
Similarity:	291/479 - (60%)	Gaps:	14/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSF 120
            |.|..|....|:...       |.|::.:.|.:||.||||.||||||||||.|:|:.:.|.|:|.
Mouse   103 DGSALGDGASPVAEQ-------VKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSL 160

  Fly   121 IIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLS 185
            :||...|:.|:.|||.||||||....|||.:||.::|:|...||:..|.|.|:::|:..|:|.::
Mouse   161 VIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAIT 225

  Fly   186 FAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGA 250
            ||.|.|:.....|..|....:::|...|.::.|:||..|..|..||::||.||::|::.||..|.
Mouse   226 FANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGI 290

  Fly   251 WKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIP 315
            .:|.||.|.:..|:|.|....:|.||.|.|:.|::|.||:.||||||||:||.:|||.||.|.:|
Mouse   291 VRLGQGATANFENSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMP 355

  Fly   316 LVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGR 380
            :||:.|.|.|::|.:.:..:|::.|:||||||.::|.|...|::|::|..|.||..|.::.||.|
Mouse   356 IVTIIYLLTNVAYYSVLDIKEILASDAVAVTFADQIFGVFNWIIPVAVAFSCFGGLNASIVAASR 420

  Fly   381 LCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAML 445
            |.|..||||||.|.:..|||.|.||.|.|:|:.:::...:....|..||:::||:.|.|.|.:::
Mouse   421 LLFVGSREGHLPDAICMVHVERFTPVPSLLFNGVLSLVYLCVEDIFQLINYYSFSYWFFVGLSIV 485

  Fly   446 ALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVK 510
            ..:.:|:..|:.|||.|:.:..|::..:.:::|||.|:: :..:..|..:....:||.||...::
Mouse   486 GQLYLRWKDPDRPRPLKLSLFFPIIFCLCTIFLVAVPLY-SDTINSLIGIGIALSGLPFYFFIIR 549

  Fly   511 L--GMTPRFMNK----VTLFFQLL 528
            :  ...|.|:.:    :|.:.|:|
Mouse   550 VPEHKRPLFLRRIVASITRYLQIL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	185/479 (39%)
Slc7a7	XP_030103562.1	2A0308	107..580	CDD:273332	183/475 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750