DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a12

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	465	Identity:	135/465 - (29%)
Similarity:	238/465 - (51%)	Gaps:	16/465 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTG-SVGVSFIIWLACGVLSLLGALAYAELG 141
            :.|.|.||:|....::....:|:||||:|..:|..:. ::.||..||..||:||::.||..||:.
Mouse     1 MQLLRALGVFHVSMILFSATLGTGIFVTPKAVLKYSSLNIPVSLSIWAGCGLLSIMSALCNAEIA 65

  Fly   142 TMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVK 206
            |....|||.:.:.....|.:.|||..|:. |......:...||..|...::.|.:.|..|....|
Mouse    66 TTYPLSGASYYFLKRTLGSSVAFLSLWIK-LFAHFLGIGAQCLLIATSVIQCFYSGCPAPELPTK 129

  Fly   207 MVALVAIVMILFVNCYSVNLGMAVQNVFTAAK-----LVAVVVVICGGAWKLMQGNTQHLSNAFN 266
            .:||..:.....|:...:........|.:..|     |:::.|::..|    .:.|.....||.:
Mouse   130 CLALAILWSFGIVSARGIKTVAWFNTVSSFIKLSVLCLISLTVLLVNG----KKENVSRFENALD 190

  Fly   267 GPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAA 331
            ..:||...||.|.....::|.|.:.|..:..|||.|::.:|:::|.||.:||:.|.|.||||||.
Mouse   191 AELPNASQIADAILQVSYSYLGSSVLIVIAGEIKRPTETIPKTLIYGISIVTVLYLLTNISYLAV 255

  Fly   332 MSPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILS 396
            ::.||:|.|::|.||:.||:..::.|:....::....||.:..:.:|.|:.::||:||....|.|
Mouse   256 LTSQEIIFSDSVGVTWMNRVFPSIQWISSFLISAFLLGSVSCGIVSASRVFYSASQEGEFPSIYS 320

  Fly   397 YVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPY 461
            .::... :||...|...:::|..::..:|..|:.:.|..::......|:.|:.:||..|:.||||
Mouse   321 MLNDHH-SPAVADIQIVILSSVAIISSSIIYLVKYVSLGSFCINLLQMIGLLKIRYQNPDIPRPY 384

  Fly   462 KV--PIIIPVVVLVISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVKLGMTPRFMNKVTLF 524
            ||  |.|...:.|  |::|:..|:.::|.:|::|.::|:|.|.:.|.....|.......:.:|.:
Mouse   385 KVWLPFIFGSIAL--SLFLIFTPVIQSPSIEHVYQVVFLFCGFLCYWLQANLNGHATCFDTITCY 447

  Fly   525 FQLLLEVVPT 534
            .|||..:.|:
Mouse   448 CQLLFNISPS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	134/461 (29%)
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	121/412 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11785
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850