DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and Slc7a3

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001288769.1	Gene:	Slc7a3 / 11989	MGIID:	1100521	Length:	618	Species:	Mus musculus

Alignment Length:	526	Identity:	120/526 - (22%)
Similarity:	212/526 - (40%)	Gaps:	77/526 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 RKPLERN-GSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFII-WLAC 126
            |:.||.. |.|:     |.|.|.....|||.||:.:|:|::|....  |.....|.|.:| :|..
Mouse    16 RRVLELGMGETR-----LARCLSTLDLVALGVGSTLGAGVYVLAGE--VAKDKAGPSIVICFLVA 73

  Fly   127 GVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSW--VSTLVLKPSQMAIICLSFAQY 189
            .:.|:|..|.|||.|.....||:.:.|.....|...||...|  :.:.|:..:.:|....|....
Mouse    74 ALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDN 138

  Fly   190 AVEAFVTECDPPRGVVKM----------VALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVV 244
            .:...::.......::||          .||..::::..:.....:....|..|||...|:.:..
Mouse   139 LIGNHISRTLKGTILLKMPHVLAEYPDFFALALVLLLTGLLVLGASKSALVTKVFTGMNLLVLSF 203

  Fly   245 VICGG-------AWKLMQGN---TQHLSN--------AFNGPMP-----NVGAIATAFYTGLWAY 286
            ||..|       .|||.:.:   |...||        ...|.||     .:...||.||    |:
Mouse   204 VIISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFY----AF 264

  Fly   287 DGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEA-VAVTFG-- 348
            .|::.:....||.:||.:::|..|:|.:.:..|.|..:: |.|..|.|...:..|: :...|.
Mouse   265 VGFDCIATTGEEAQNPQRSIPMGIVISMFICFLAYFGVS-SALTLMMPYYKLHPESPLPEAFSYV 328

  Fly   349 ----NRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGL 409
                .|.|.|:..|..||.::.      |::|...|:.::.:.:|.|..:|:.||.....|....
Mouse   329 GWEPARYLVAIGSLCALSTSLL------GSMFPMPRVMYSMAEDGLLFRVLAKVHSVTHIPIVAT 387

  Fly   410 IFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVL-- 472
            :...:||:.|.....:..|:|..|....:.:....:.::::||......:..:..:.:....|
Mouse   388 LVSGVIAAFMAFLFELTDLVDLMSIGTLLAHSLVSICVLILRYQPDQEMKSVEEEMELQEETLEA 452

  Fly   473 -VISVYLVAAPIFETP-----RVEY----LYALLFIFAGLI--FYVPFVKLGMTPRFMNKVTLFF 525
             .::|..:..|:...|     ||.|    |.|:|.....|:  ::...::.| .|.::..|.|..
Mouse   453 EKLTVQALFCPVNSIPTLLSGRVVYVCSSLLAVLLTVLCLVLTWWTTPLRSG-DPVWVTVVVLIL 516

  Fly   526 QLLLEV 531
            .|:|.:
Mouse   517 GLILAI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	120/526 (23%)
Slc7a3	NP_001288769.1	2A0303	4..588	CDD:273330	120/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010