DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbm and slc7a8b

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_001346314.3	Gene:	slc7a8b / 100007990	ZFINID:	ZDB-GENE-030616-586	Length:	501	Species:	Danio rerio

Alignment Length:	483	Identity:	191/483 - (39%)
Similarity:	291/483 - (60%)	Gaps:	8/483 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFI 121
            |.||.|....:..:.......|.|::.:||.|...::||.:|||||||||.|:|..:||||::.|
Zfish     3 SGGTRRRTASVPDSDPDGEPAVTLKKEIGLLSACGIVVGNIIGSGIFVSPKGVLENSGSVGLALI 67

  Fly   122 IWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSF 186
            :|:..|:::.:|||.|||||.....||.:::|..|.:|....||..|::.||:.|:..|:|.|:|
Zfish    68 VWILTGIITAIGALCYAELGVTIPKSGGDYSYVNDIFGGLAGFLRLWIAVLVIYPTNQAVIALTF 132

  Fly   187 AQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAW 251
            |.||::.....|.||...:.::|.|.::::.::||.||.....||:|||..||:|:.::|..|..
Zfish   133 ANYALQPLFPSCFPPERALGLLAAVCLLLLTWINCSSVRWATRVQDVFTTGKLLALGLIIIMGIV 197

  Fly   252 KLMQGNTQHL--SNAFNGPMP-NVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIG 313
            ::.:|:...|  .:||:...| ::|.||.|...|.:||.|||.|||||||:.:|.:||||:|.|.
Zfish   198 QICKGHFYWLEPEHAFHPLQPYDMGRIALAVLQGSFAYAGWNFLNYVTEELIDPYRNLPRAIFIS 262

  Fly   314 IPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAA 378
            |||||..|...||:|:.||||||::.|.|||||||.::||.::||||:||.:||||..||:||.:
Zfish   263 IPLVTFVYVSANIAYVTAMSPQELLASNAVAVTFGEKLLGVMSWLMPISVALSTFGGVNGSLFTS 327

  Fly   379 GRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGA 443
            .||.||.:|||||..:|:.:||.|.||.|.|:...:....|:....|.:||::..|..::|||..
Zfish   328 SRLFFAGAREGHLPRLLAMIHVNRCTPIPALLITCISTLLMLCVSDIYTLINYVGFINYLFYGVT 392

  Fly   444 MLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPF 508
            :...||:|..:|:..||.||.:..|.|.|:...:|:...::..| |.....|..:.:|:..|:..
Zfish   393 VAGQIVLRIREPDIYRPIKVSLAWPAVFLIFWAFLLIFSLYSEP-VVCCIGLAIMLSGVPVYLFG 456

  Fly   509 VKLGMTPR----FMNKVTLFFQLLLEVV 532
            :.....|:    |:.::|...|.|..||
Zfish   457 IYWENKPKSFSSFVARLTHLGQKLCLVV 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	189/481 (39%)
slc7a8b	XP_001346314.3	AA_permease_2	9..488	CDD:330980	187/477 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730