DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbm and slc7a8a

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001258826.1	Gene:	slc7a8a / 100007704	ZFINID:	ZDB-GENE-121120-2	Length:	531	Species:	Danio rerio

Alignment Length:	499	Identity:	198/499 - (39%)
Similarity:	299/499 - (59%)	Gaps:	20/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TEGPE-----APETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSP 106
            |:||.     ||.|.|...|     ....|:|....|.|::.:||.|...:|||.:|||||||||
Zfish     2 TDGPRQRGSAAPSTASEDGG-----AADTGNTAGQSVALKKEIGLVSACGIIVGNIIGSGIFVSP 61

  Fly   107 SGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVST 171
            .|:|....|||::.|:|:..|:::.:|||.|||||.....||.:::|..|.:|....||..|::.
Zfish    62 KGVLENASSVGLALIVWILTGIITAIGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAV 126

  Fly   172 LVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTA 236
            ||:.|:..|:|.|:|:.|.::.....|.||...::::|.:.::::.:|||.||.....||:||||
Zfish   127 LVIYPTNQAVIALTFSNYVLQPLFPTCFPPENGLRILAAICLLLLTWVNCSSVRWATRVQDVFTA 191

  Fly   237 AKLVAVVVVICGGAWKLMQGNTQHL--SNAFNGPMP--NVGAIATAFYTGLWAYDGWNNLNYVTE 297
            .||:|::::|..|..::.:|....|  :|||. |..  :||.||.||..|.:||.|||.||||||
Zfish   192 GKLLALILIIIMGIVQICKGEYYWLEPANAFE-PFQDYDVGLIALAFLQGSFAYGGWNFLNYVTE 255

  Fly   298 EIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLS 362
            |:.:|..||||:|.|.|||||..|...||:|:.||||||::.|.|||||||.::||.::|:||:|
Zfish   256 ELVDPYVNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMSWIMPIS 320

  Fly   363 VTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDS 427
            |.:||||..||:||.:.||.||.:|||||..:|:.:||:|.||.|.|:|..:....|:....:.:
Zfish   321 VALSTFGGVNGSLFTSSRLFFAGAREGHLPSLLAMIHVKRCTPIPALLFTCISTLLMLCTSDMYT 385

  Fly   428 LIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYL 492
            ||::..|..::|||..:...||:|..:|:..||.|:.::.||:.|:...:|:...::..|.|..:
Zfish   386 LINYVGFINYLFYGVTVAGQIVLRIKQPDMHRPIKISLVWPVIYLLFWAFLLIFSLYSEPVVCGI 450

  Fly   493 YALLFIFAGLIFYVPFVKLGMTPR----FMNKVTLFFQLLLEVV 532
             .|..:..|:..|...|.....|:    |::|:|...|....||
Zfish   451 -GLAIMLTGVPVYFLGVYWDNKPQCFNTFVDKMTYLGQKFCVVV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	192/486 (40%)
slc7a8a	NP_001258826.1	2A0308	1..497	CDD:273332	198/499 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D621852at2759
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760