DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbm and slc7a3b

DIOPT Version :9

Sequence 1:	NP_727785.1	Gene:	sbm / 32397	FlyBaseID:	FBgn0030574	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_001342962.3	Gene:	slc7a3b / 100003376	ZFINID:	ZDB-GENE-120813-6	Length:	698	Species:	Danio rerio

Alignment Length:	586	Identity:	121/586 - (20%)
Similarity:	241/586 - (41%)	Gaps:	113/586 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VPTKTTSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALI 93
            :|..:||:..|..|           :..|.|...:|:.:..:...::|.......|.|   :||.
Zfish    43 IPVSSTSSSIMTKN-----------KLASFGKMLLRRRVLDDSPVESHFARCLTTLDL---IALG 93

  Fly    94 VGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAY 158
            ||..:|:|::|. :|.:.|..:.....:.:|...:.|:|..|.|||.|.....:|:.:.|.....
Zfish    94 VGATLGAGVYVL-AGEVAREKAGPAIVLSFLIAALSSVLAGLCYAEFGARVPKTGSAYVYSYVTV 157

  Fly   159 GPAPAFLFSW--VSTLVLKPSQMA---------IICLSFAQYAVEAFVTECDPPRGVVK---MVA 209
            |...||:..|  :.:.|:..:.:|         ::....:.: .:||::..|....:.|   :.|
Zfish   158 GEIWAFITGWNLILSYVIGTASVARAWSATFDSLLAQKISTF-FKAFMSFPDTQNVLAKYPDVFA 221

  Fly   210 LVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNT---------------- 258
            |:.::::..:..:.|:....|..:||...||.:..||..|   .::|:|
Zfish   222 LILVMLLTGLLAFGVSESALVNKIFTGINLVVLTFVIISG---FVKGDTANWNLTVEDYINRTNI 283

  Fly   259 ---QHLSNAF----------NGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSI 310
               |.:...|          ||.:.  || ||.||    |:.|::.:...:||.|||.:::|..|
Zfish   284 TGAQKIEKEFGSGGFAPFGLNGVLS--GA-ATCFY----AFVGFDCIATTSEEAKNPMRSIPIGI 341

  Fly   311 IIGIPLVTLCYALINISYLAAMSPQEMIESEA-VAVTFGNRILGALAWLMPLSVTISTFGSANGT 374
            :..:.:....|..::.: |..|.|..|::..: :...|.....|...:::.:....:...|..|:
Zfish   342 VASLLICFFAYFGVSAA-LTLMMPYYMLDKHSPLPQAFDYVGWGPARYIVSVGSLCALSTSLLGS 405

  Fly   375 LFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIF 439
            :|...|:.:|.:.:|.|...||.:|.:..|||...:...::|:.|.....:|:|:|..|....:.
Zfish   406 MFPMPRVIYAMAEDGLLFRFLSRMHKKTKTPALATLVSGIVAALMAFLFDLDALVDLMSIGTLLA 470

  Fly   440 YGGAMLALIVMRYTKPNY-------PRPYKVPIIIPVVVLVI-------------------SVYL 478
            |....:.::::|| :|:.       .:|.::..:....|:.:                   |:.:
Zfish   471 YTLVAVCVLILRY-QPSRLGSSGADVKPVELQRLEAKAVMDVDSGDEYSQDMETIPLKKRFSIRM 534

  Fly   479 VAAPIFETPR-----VEY----LYALLFIFAGLIFYVPFVKLGM-TPRFMNKVTLFFQLLLEVVP 533
            :..||.:.|.     :.|    ..::||....|:..|...::.| .|.|:..|     :||.|:.
Zfish   535 LVQPICDVPTKISGIIVYSACGTISVLFTLLCLVLSVCLEQVAMGHPLFICLV-----VLLSVLS 594

  Fly   534 T 534
            |
Zfish   595 T 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbm	NP_727785.1	2A0308	53..532	CDD:273332	114/558 (20%)
slc7a3b	XP_001342962.3	2A0303	57..665	CDD:273330	116/561 (21%)
slc7a3b	XP_001342962.3	AA_permease_C	613..663	CDD:290617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010