Protein Alignment dpr8 and CD86

DIOPT Version :10

• Sequence 1: NP_727781.1
• Gene: dpr8 / 32387
• FlyBaseID: FBgn0052600
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_787058.5
• Gene: CD86 / 942
• HGNCID: 1705
• Length: 329
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 81/361 - (22%)
• Similarity: 137/361 - (37%)
• Gaps: 97/361 - (26%)

  Fly    18 CTDGASKRFFT-DFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVKLTCRVKNLGNRTVS-----W 76
            ||.|.|...|. .||.....|            ..|.....:|..|.|:..|..|:::|     |
Human     5 CTMGLSNILFVMAFLLSGAAP------------LKIQAYFNETADLPCQFANSQNQSLSELVVFW 57

  Fly    77 VRHRDIHLLTVGRYTYTSDQRFEAMHSPH-------AEDWTLRIRYAQRKDSGIYECQISTTPPI 134
            ....::.|..|    |...::|:::||.:       ::.||||:...|.||.|:|:|.|....|.
Human    58 QDQENLVLNEV----YLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPT 118

  Fly   135 G----H------SVYLNIVEPVTDIIGGPELHINRGSTINLTC-IVKFAPEPPP-TVIWSHNREI 187
            |    |      ||..|..:|  :|:  |..:|.....||||| .:...|||.. :|:.......
Human   119 GMIRIHQMNSELSVLANFSQP--EIV--PISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNST 179

  Fly   188 INFDSPRGGI-----SLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSN-----ANPTSVRVHIVD 242
            |.:|    |:     ..|||...::.|..:....:|.:..::....::     ::|.|:.:
Human   180 IEYD----GVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIEL---- 236

  Fly   243 GEHPAAMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQASTFAE 307
             |.|             ..||..:|.:.....|:::..:| .|..|                :..
Human   237 -EDP-------------QPPPDHIPWITAVLPTVIICVMV-FCLIL----------------WKW 270

  Fly   308 EKAMGQRSNRNC-QDLQELEESQDLRRRGVERSAVP 342
            :|....|::..| .:..|.|||:..::|  |:..:|
Human   271 KKKKRPRNSYKCGTNTMEREESEQTKKR--EKIHIP 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_727781.1	IG_like	51..131	CDD:214653	25/91 (27%)
		Ig strand B	60..64	CDD:409353	1/3 (33%)
		Ig strand C	73..77	CDD:409353	1/8 (13%)
		Ig strand E	109..113	CDD:409353	3/3 (100%)
		Ig strand F	123..128	CDD:409353	2/4 (50%)
		Ig_3	153..230	CDD:464046	19/83 (23%)
CD86	NP_787058.5	IgV_CD86	26..133	CDD:409508	29/110 (26%)
		FR1	26..40	CDD:409508	3/13 (23%)
		Ig strand A	26..31	CDD:409508	1/4 (25%)
		Ig strand B	34..40	CDD:409508	2/5 (40%)
		CDR1	41..52	CDD:409508	2/10 (20%)
		FR2	53..60	CDD:409508	1/6 (17%)
		Ig strand C	53..59	CDD:409508	1/5 (20%)
		CDR2	62..82	CDD:409508	6/23 (26%)
		Ig strand C'	64..69	CDD:409508	2/8 (25%)
		Ig strand C'	72..74	CDD:409508	0/1 (0%)
		FR3	83..115	CDD:409508	11/31 (35%)
		Ig strand D	85..89	CDD:409508	0/3 (0%)
		Ig strand E	93..99	CDD:409508	4/5 (80%)
		Ig strand F	106..114	CDD:409508	4/7 (57%)
		CDR3	116..118	CDD:409508	0/1 (0%)
		FR4	119..133	CDD:409508	3/13 (23%)
		Ig strand G	120..133	CDD:409508	2/12 (17%)
		Ig	136..221	CDD:472250	21/92 (23%)
		Ig strand B	152..157	CDD:409505	3/4 (75%)
		Ig strand C	167..172	CDD:409505	0/4 (0%)
		Ig strand E	201..205	CDD:409505	1/3 (33%)
		Ig strand F	215..220	CDD:409505	0/4 (0%)