DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	311	Identity:	70/311 - (22%)
Similarity:	97/311 - (31%)	Gaps:	95/311 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DFLQDLPTPGTGGP---------------TFDTTIGTNITGLVGKTVKLTCRVKNLGNRTVSWVR 78
            |..||....|..||               ..|......:....|:.:::|||.:......:.|.|
Human  1015 DPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQR 1079

  Fly    79 HRDIHLLTVGRYTYTSDQRFEAMHSPHAE---DWTLRIRYAQRKDSGIYECQISTTPPIGHS--- 137
            ..                  :.:.||..:   |.:|.|.....:|.|.|.|....    |..
Human  1080 DG------------------QPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFN----GQDRDQ 1122

  Fly   138 --VYLNIVEPVTDIIGG--PELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFD------S 192
              |.|.::..:|  |.|  |.:.:..|.|..|.|:|  |.| ...:.||.|...:..|      |
Human  1123 RWVQLRVLGELT--ISGLPPTVTVPEGDTARLLCVV--AGE-SVNIRWSRNGLPVQADGHRVHQS 1182

  Fly   193 PRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTP---SNANPTSVRVHIVDGEHPA-AMHTGN 253
            |.|              .||:.....:|.|.|||:.   |.|...|..|.:|.   || .....:
Human  1183 PDG--------------TLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVS---PAPTAQPRD 1230

  Fly   254 NGNSTASQPPVLLPLVLLTCSTLMLLQL----------VASCSTLVPATPP 294
            .|.....||.      |..|..::..||          .||||...|...|
Human  1231 PGRDCVDQPE------LANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQP 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	15/82 (18%)
		V-set	52..143	CDD:284989	18/98 (18%)
		IG_like	153..238	CDD:214653	25/93 (27%)
		ig	153..232	CDD:278476	23/87 (26%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767
		Ig	914..>978	CDD:325142
		I-set	1049..1119	CDD:254352	16/91 (18%)
		IG	1139..1219	CDD:214652	26/96 (27%)
		PLAC	1235..1267	CDD:312271	8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900