DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	243	Identity:	58/243 - (23%)
Similarity:	92/243 - (37%)	Gaps:	53/243 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VKLTCRVKNLGNRTVSW-VRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGI 123
            |.|.|..:......|:| :|.:|:.               :.......::.|||||..:|..||:
Human   154 VTLRCVARGSPLPHVTWKLRGKDLG---------------QGQGQVQVQNGTLRIRRVERGSSGV 203

  Fly   124 YECQISTTP-PIGHSVYLNIVEPVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREI 187
            |.||.|:|. ...|:..|.::.|...::......:|....::|.|   .|...|..:.:|..::.
Human   204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC---HAEAYPANLTYSWFQDN 265

  Fly   188 IN-FDSPRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNA--NPTSVRVHIVDGEHPAAM 249
            || |...|    |.....:|....|.:......|:|.|||.|||.  :|.|...::. ..:||.:
Human   266 INVFHISR----LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLT-VLYPAQV 325

  Fly   250 HTGNNGNSTASQPPVLLPLVL---LTCSTLMLLQLVASCSTLVPATPP 294
                    ||..|...||:.:   :.|.              |.|.||
Human   326 --------TAMPPETPLPIGMPGVIRCP--------------VRANPP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	19/71 (27%)
		V-set	52..143	CDD:284989	22/84 (26%)
		IG_like	153..238	CDD:214653	23/87 (26%)
		ig	153..232	CDD:278476	21/81 (26%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	22/83 (27%)
		Ig	154..220	CDD:143165	21/80 (26%)
		Ig_3	226..305	CDD:290638	20/85 (24%)
		IG_like	233..319	CDD:214653	23/93 (25%)
		Ig	341..404	CDD:299845	5/25 (20%)
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810