DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and DSCAML1

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens

Alignment Length:	302	Identity:	71/302 - (23%)
Similarity:	106/302 - (35%)	Gaps:	70/302 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SKRFFTDFLQDLPTPGTG------GPTFDTTIGTNI-----------------TGLVGKTVKLTC 64
            :||.....:.||.|..:|      ..||.:...|.|                 || :|.||.|:|
Human   285 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTG-IGSTVILSC 348

  Fly    65 RVKNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGIYECQIS 129
            .:......|:.|.|:.::.|..            ||:......:.||.|..||:..||.|:|..:
Human   349 ALTGSPEFTIRWYRNTELVLPD------------EAISIRGLSNETLLITSAQKSHSGAYQCFAT 401

  Fly   130 TTPPIGHSVYLNIVEPVTD--IIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFDS 192
            ..........:..:|..|.  :....|..:|.|...:|.|..|.|  |||||.|:.:.|.|..|.
Human   402 RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA--PPPTVTWALDDEPIVRDG 464

  Fly   193 PRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNANPTSVRVHIVDGEHPAAMHTGNNGNS 257
            ...........|. |.|.:.|.....:|.|:|.||..|.        :...|:.|.::...
Human   465 SHRTNQYTMSDGT-TISHMNVTGPQIRDGGVYRCTARNL--------VGSAEYQARINVRG---- 516

  Fly   258 TASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTV 299
                ||.:..:..:|.        ||...||:     .||.:
Human   517 ----PPSIRAMRNITA--------VAGRDTLI-----NCRVI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	23/96 (24%)
		V-set	52..143	CDD:284989	23/107 (21%)
		IG_like	153..238	CDD:214653	26/84 (31%)
		ig	153..232	CDD:278476	26/78 (33%)
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653
		IGc2	43..110	CDD:197706
		Ig	125..218	CDD:299845
		IG_like	137..209	CDD:214653
		I-set	245..323	CDD:254352	10/37 (27%)
		IGc2	252..313	CDD:197706	7/27 (26%)
		IGc2	340..401	CDD:197706	20/72 (28%)
		I-set	420..514	CDD:254352	28/104 (27%)
		Ig	420..510	CDD:299845	27/100 (27%)
		IGc2	531..589	CDD:197706	4/16 (25%)
		IG_like	619..698	CDD:214653
		Ig	627..693	CDD:143165
		I-set	702..797	CDD:254352
		Ig7_DSCAM	719..797	CDD:143211
		I-set	803..896	CDD:254352
		Ig	815..903	CDD:299845
		FN3	899..993	CDD:238020
		FN3	1000..1097	CDD:238020
		fn3	1105..1191	CDD:278470
		FN3	1203..1294	CDD:238020
		IGc2	1318..1382	CDD:197706
		FN3	1396..1486	CDD:238020
		FN3	1500..1572	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910