DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr8 and OPCML

DIOPT Version :9

Sequence 1:NP_001285239.1 Gene:dpr8 / 32387 FlyBaseID:FBgn0052600 Length:344 Species:Drosophila melanogaster
Sequence 2:NP_001306032.1 Gene:OPCML / 4978 HGNCID:8143 Length:354 Species:Homo sapiens


Alignment Length:273 Identity:68/273 - (24%)
Similarity:109/273 - (39%) Gaps:41/273 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IFLGILCLLAGCTDGASKRFFTDFLQDLPTP-GTGGPTFDTTIGTNITGLVGKTVKLTCRVKNLG 70
            :||...||:.     .|.|..  ||.....| .:|..||...: .|:|...|::..|.|.:.:..
Human     7 LFLPWKCLVV-----VSLRLL--FLVPTGVPVRSGDATFPKAM-DNVTVRQGESATLRCTIDDRV 63

  Fly    71 NRTVSWVRHRDIHLLTVGRYTYTSDQR-FEAMHSPHAEDWTLRIRYAQRKDSGIYECQIST-TPP 133
            .| |:|:....|  |..|...::.|.| ...:::|  ..:::.|:.....|.|.|.|.:.| ..|
Human    64 TR-VAWLNRSTI--LYAGNDKWSIDPRVIILVNTP--TQYSIMIQNVDVYDEGPYTCSVQTDNHP 123

  Fly   134 IGHSVYLNIVEPVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFDSPRGGIS 198
            ....|:|.:..|...:....::.:|.||::.|.|:....||  |||.|.|             :|
Human   124 KTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPE--PTVTWRH-------------LS 173

  Fly   199 LVTEKGVLTTSRLLVQKAITQD-SGLYTCTPSN--ANPTSVRVHIVDGEHPAAMHTGNNGNSTAS 260
            :...:|.::....|....|.:| ||.|.|:..|  |.|...:|.|.....|......|.|.|...
Human   174 VKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQ 238

  Fly   261 QPPVLLPLVLLTC 273
            :.       :|:|
Human   239 KG-------ILSC 244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr8NP_001285239.1 IG_like 51..131 CDD:214653 20/81 (25%)
V-set 52..143 CDD:284989 22/92 (24%)
IG_like 153..238 CDD:214653 24/87 (28%)
ig 153..232 CDD:278476 22/81 (27%)
OPCMLNP_001306032.1 Ig 44..132 CDD:416386 23/92 (25%)
Ig strand A' 44..49 CDD:409353 2/4 (50%)
Ig strand B 51..59 CDD:409353 2/7 (29%)
CDR1 59..63 CDD:409353 0/3 (0%)
FR2 64..70 CDD:409353 3/6 (50%)
Ig strand C 64..70 CDD:409353 3/6 (50%)
CDR2 71..83 CDD:409353 3/13 (23%)
Ig strand C' 72..76 CDD:409353 1/5 (20%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 8/35 (23%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 1/3 (33%)
Ig strand G 123..132 CDD:409353 3/8 (38%)
FR4 125..132 CDD:409353 2/6 (33%)
Ig_3 135..206 CDD:404760 22/85 (26%)
Ig strand A 135..138 CDD:409353 1/2 (50%)
Ig strand A' 144..148 CDD:409353 0/3 (0%)
Ig strand B 151..160 CDD:409353 3/8 (38%)
Ig strand C 165..170 CDD:409353 3/4 (75%)
Ig strand C' 171..174 CDD:409353 1/15 (7%)
Ig strand F 198..206 CDD:409353 3/7 (43%)
Ig 224..312 CDD:416386 6/28 (21%)
putative Ig strand A 224..230 CDD:409353 1/5 (20%)
Ig strand B 240..244 CDD:409353 1/10 (10%)
Ig strand C 253..257 CDD:409353
Ig strand E 279..283 CDD:409353
Ig strand F 293..298 CDD:409353
Ig strand G 306..309 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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