DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and NCAM1

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	361	Identity:	82/361 - (22%)
Similarity:	130/361 - (36%)	Gaps:	98/361 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CLLAGCTDGAS-------KRFFTDFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVKLTCRVKNLG 70
            |::.| .||:.       |.|.....::.|||    ..|..          |:...:.|.|.:..
Human    96 CVVTG-EDGSESEATVNVKIFQKLMFKNAPTP----QEFRE----------GEDAVIVCDVVSSL 145

  Fly    71 NRTVSWVRH--RDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGIYECQ------ 127
            ..|:.| :|  ||:.|        ..|.||..:.:.:     |:||..::.|.|.|.|:
Human   146 PPTIIW-KHKGRDVIL--------KKDVRFIVLSNNY-----LQIRGIKKTDEGTYRCEGRILAR 196

  Fly   128 ----------ISTTPPIGHSVYLNIVEPVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWS 182
                      |...||        .::...:|:...   .|.|.::.|.|..:..||  ||:.|:
Human   197 GEINFKDIQVIVNVPP--------TIQARQNIVNAT---ANLGQSVTLVCDAEGFPE--PTMSWT 248

  Fly   183 HNREIINFDSPRGGISLVTEKGVLT--TSRLLVQKAITQDSGLYTCTPSN-ANPTSVRVHIVDGE 244
            .:.|.|..:..       .||.:.:  :|:|.::|....|...|.|...| |......:|:....
Human   249 KDGEQIEQEED-------DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306

  Fly   245 HPAAMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQASTFAEEK 309
            .|...:.   .|.||.:   |...|.|||.        ||...:...|   .|| ...:..:|||
Human   307 KPKITYV---ENQTAME---LEEQVTLTCE--------ASGDPIPSIT---WRT-STRNISSEEK 353

  Fly   310 AMGQRSNRNCQDLQELEESQDLRRRGVERSA-VPGT 344
            |...|..:  |::......|..|::|...|| .||:
Human   354 ASWTRPEK--QEVHAPWNWQVGRQKGQAGSAGFPGS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	20/97 (21%)
		V-set	52..143	CDD:284989	22/108 (20%)
		IG_like	153..238	CDD:214653	21/87 (24%)
		ig	153..232	CDD:278476	20/81 (25%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	5/19 (26%)
		IG	124..190	CDD:214652	22/93 (24%)
		Ig	211..307	CDD:325142	25/115 (22%)
		Ig	306..438	CDD:325142	27/102 (26%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810