DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpr8 and Negr1

DIOPT Version :9

Sequence 1:NP_001285239.1 Gene:dpr8 / 32387 FlyBaseID:FBgn0052600 Length:344 Species:Drosophila melanogaster
Sequence 2:XP_036019026.1 Gene:Negr1 / 320840 MGIID:2444846 Length:362 Species:Mus musculus


Alignment Length:387 Identity:73/387 - (18%)
Similarity:113/387 - (29%) Gaps:150/387 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 STHWIIFLGILCLLAGCTDGASKRFFTDFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVKLTCRV 66
            |..|:  ..:|..|..|                 .|......|......|:....|.|..|.|.:
Mouse    11 SNQWL--AAVLLSLCSC-----------------LPAGQSVDFPWAAVDNMLVRKGDTAVLRCYL 56

  Fly    67 KNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGIYECQISTT 131
            :: |....:|:....|  :..|...::.|.|. ::.:.:..|::|:|:.....|.|.|.|.:.|.
Mouse    57 ED-GASKGAWLNRSSI--IFAGGDKWSVDPRV-SISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQ 117

  Fly   132 -PPIGHSVYLNIVEP--VTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSH---------- 183
             .|....|:|.:..|  :.||  ..::.||.|:.:.|||:....||  |.:.|.|          
Mouse   118 HTPRTMQVHLTVQVPPKIYDI--SNDMTINEGTNVTLTCLATGKPE--PVISWRHISPSAKPFEN 178

  Fly   184 --------------------------------NREIINFDSP-------------RGGISLVTEK 203
                                            .|.|:|| :|             |.|:......
Mouse   179 GQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVIVNF-APTIQEIKSGTVTPGRSGLIRCEGA 242

  Fly   204 GV-------------------------LTTSRLLVQKAITQDS-GLYTCTPSNANPTSVRVHIVD 242
            ||                         .:|..:|....:||:. |.|||..:|            
Mouse   243 GVPPPAFEWYKGEKRLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAAN------------ 295

  Fly   243 GEHPAAMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQAST 304
                      ..|.:.||.|                |..:...:|..|.|.|...|.|...|
Mouse   296 ----------KLGTTNASLP----------------LNQIIEPTTSSPVTSPAPSTAQYGIT 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr8NP_001285239.1 IG_like 51..131 CDD:214653 18/79 (23%)
V-set 52..143 CDD:284989 21/91 (23%)
IG_like 153..238 CDD:214653 29/165 (18%)
ig 153..232 CDD:278476 29/159 (18%)
Negr1XP_036019026.1 FR1 38..55 CDD:409353 4/16 (25%)
Ig strand A' 40..46 CDD:409353 1/5 (20%)
IG_like 41..129 CDD:214653 22/91 (24%)
Ig strand B 48..56 CDD:409353 3/7 (43%)
CDR1 56..60 CDD:409353 0/4 (0%)
FR2 61..68 CDD:409353 1/6 (17%)
Ig strand C 61..67 CDD:409353 1/5 (20%)
CDR2 69..79 CDD:409353 2/11 (18%)
Ig strand C' 71..74 CDD:409353 1/4 (25%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 9/35 (26%)
Ig strand D 84..91 CDD:409353 1/7 (14%)
Ig strand E 94..100 CDD:409353 2/5 (40%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 1/3 (33%)
Ig strand G 120..129 CDD:409353 3/8 (38%)
FR4 122..129 CDD:409353 2/6 (33%)
Ig strand A' 139..144 CDD:409353 0/4 (0%)
IGc2 146..204 CDD:197706 9/59 (15%)
Ig strand B 150..157 CDD:409353 3/6 (50%)
Ig strand C 163..168 CDD:409353 1/4 (25%)
Ig strand C' 170..172 CDD:409353 0/1 (0%)
Ig strand E 180..186 CDD:409353 0/5 (0%)
Ig strand F 193..200 CDD:409353 0/6 (0%)
Ig_3 219..295 CDD:404760 13/75 (17%)
putative Ig strand A 219..225 CDD:409353 1/5 (20%)
Ig strand B 235..239 CDD:409353 1/3 (33%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.