DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and LRIT1

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens

Alignment Length:	226	Identity:	46/226 - (20%)
Similarity:	69/226 - (30%)	Gaps:	76/226 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GPTFDTTIGTNITGLVGKTVKLTCRVKNLGNRTVSWVR----------HRDIHLLTVGRYTYTSD 95
            ||.....: .:|..|:|.|..|.|....:....:||.|          |:::
Human   253 GPELHPGV-ASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEV------------- 303

  Fly    96 QRFEAMHSPHAEDWT-LRIRYAQRKDSGIYECQISTTPPIGHS---VYLNIVEPVTDII------ 150
                   |.....|| |.:......|||.|.||....  :|.|   :.|.:.||.|...
Human   304 -------SSDGTSWTLLGLPAVSHLDSGDYICQAKNF--LGASETVISLIVTEPPTSTEHSGSPG 359

  Fly   151 -------GGPELHINRGSTINLTCIVKFAPE-PPPTVIWSHNREIINFDSPRGGISLVTEKGVLT 207
                   ||.|     .:..|...:.:..|: |.|.|:.:             |.|:.:.|..||
Human   360 ALWARTGGGGE-----AAAYNNKLVARHVPQIPKPAVLAT-------------GPSVPSTKEELT 406

  Fly   208 TSRLLVQKAITQDSGLYTCTPSNANPTSVRV 238
            ....       |...|...:...|.|:..|:
Human   407 LEHF-------QMDALGELSDGRAGPSEARM 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	20/90 (22%)
		V-set	52..143	CDD:284989	23/104 (22%)
		IG_like	153..238	CDD:214653	15/85 (18%)
		ig	153..232	CDD:278476	13/79 (16%)
LRIT1	NP_056428.1	LRR 1	60..81
		leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..143	CDD:290566
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..202	CDD:290566
		LRR_4	131..171	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599
		Ig	267..345	CDD:299845	21/99 (21%)
		IG_like	267..345	CDD:214653	21/99 (21%)
		FN3	431..498	CDD:214495	46/226 (20%)
		LRR 6. /evidence=ECO:0000305	571..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900