DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	229	Identity:	55/229 - (24%)
Similarity:	91/229 - (39%)	Gaps:	38/229 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PTFDTTIGTNITGLVGKTVKLTCRVKNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHA 106
            |||..|....|....|.::.:||.........|:|::...: |...|:|              ..
Human   139 PTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTL-LGASGKY--------------QV 188

  Fly   107 EDWTLRIRYAQRKDSGIYECQ-ISTTPPIGHSVYLNIVEPVTDIIGGPE-LHINRGSTINLTCIV 169
            .|.:|.:....|:|.|.|.|: .|......|:.:| :|:....|:..|| :.:|......|||..
Human   189 SDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHL-LVQGPPFIVSPPENITVNISQDALLTCRA 252

  Fly   170 KFAPEPPPTVIWSHNREIINFDSPRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNA--- 231
            :..| ...|..|....|.:.|.:     .|.....:|....|::.:...:|||.|||.|||:
Human   253 EAYP-GNLTYTWYWQDENVYFQN-----DLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGR 311

  Fly   232 NPTSVRVHIVDGEHPAAMHTGNNGNSTASQPPVL 265
            :|::.....|  ::||.:         .:.|||:
Human   312 SPSASAYLTV--QYPARV---------LNMPPVI 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	17/80 (21%)
		V-set	52..143	CDD:284989	19/91 (21%)
		IG_like	153..238	CDD:214653	24/88 (27%)
		ig	153..232	CDD:278476	23/82 (28%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653
		Ig	41..115	CDD:143165
		I-set	139..225	CDD:254352	23/101 (23%)
		IGc2	153..210	CDD:197706	15/71 (21%)
		I-set	229..321	CDD:254352	25/97 (26%)
		Ig	235..321	CDD:299845	24/91 (26%)
		IG_like	331..414	CDD:214653	3/4 (75%)
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810