DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr8 and Papln

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	266	Identity:	66/266 - (24%)
Similarity:	95/266 - (35%)	Gaps:	76/266 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GKTVKLTCRVKNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDS 121
            |:.::||||.:.....|:.|  .||..|::..|:..             ..|.:|.|.....:|.
Mouse  1080 GQRIRLTCRAEGFPVPTIEW--QRDGQLVSSPRHQV-------------QPDGSLVISRVDVEDG 1129

  Fly   122 GIYECQISTTPPIGHS-----VYLNIVEPVTDIIG-GPELHINRGSTINLTCIVKFAPEPPPTVI 180
            |.|.|....    |..     |.|.::..:| |.| .|.:.:..|.|..|.|:|  |.| ...:.
Mouse  1130 GYYSCVAFN----GQDRDQRWVQLRVLRELT-ITGLPPAVTVAEGDTARLLCVV--AGE-SVNIR 1186

  Fly   181 WSHNREIINFD------SPRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTC-----TPSNANPT 234
            ||.|...|..|      ||.|              .||:.....:|.|.|||     :.:.:..|
Mouse  1187 WSRNGLPIQADGHRVHQSPDG--------------TLLIHNLRPRDEGSYTCSAFRGSQAVSRST 1237

  Fly   235 SVRVHIVDGEHPA-AMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQL----------VASCSTL 288
            .|:|.:     || |..:.:.|.....||.      |..|:.::..||          .||||..
Mouse  1238 EVKVAL-----PAPAAQSRDLGKDCIDQPE------LANCALILQAQLCGNEYYSSFCCASCSRF 1291

  Fly   289 VPATPP 294
            .|...|
Mouse  1292 QPNAQP 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	18/73 (25%)
		V-set	52..143	CDD:284989	21/90 (23%)
		IG_like	153..238	CDD:214653	25/95 (26%)
		ig	153..232	CDD:278476	23/89 (26%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064
		I-set	1070..1141	CDD:369462	19/79 (24%)
		Ig	1157..1241	CDD:386229	27/100 (27%)
		PLAC	1257..1289	CDD:370061	8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900