DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr8 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	69/297 - (23%)
Similarity:	103/297 - (34%)	Gaps:	76/297 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 THWIIFLGI------LCLLAGCTDGASKRFFTDFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVK 61
            |.|::..||      :.||.|.:        ..|||.               ..::..|:|:..:
  Rat     9 TPWVLHKGIPFLSSAIPLLLGSS--------PHFLQQ---------------PEDMVVLLGQEAR 50

  Fly    62 LTCRVKNLG--NRTVSWVR-------HRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQ 117
            |.|.   ||  ...|.|.:       .||  |....|| :.|.......|..|       |:..:
  Rat    51 LPCA---LGAYRGLVQWTKDGLALGGERD--LPGWSRY-WISGNSASGQHDLH-------IKPVE 102

  Fly   118 RKDSGIYECQISTTPPIGHSVYLNIVEP--VTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVI 180
            .:|...||||.|..........|:::.|  ...::|||.:.:..|...||||..:....|.|.::
  Rat   103 LEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDARPAPELL 167

  Fly   181 WSHNREIINFDSPRGGISLVTEKGVLTTSRLLVQKAITQDSG--LYTCTPSNANP----TSVRVH 239
            |.  |:.|..|........:.:|...|....|.....:||.|  |.....|.|.|    |:|.:.
  Rat   168 WF--RDGIRLDGTSFHQITLRDKATGTVENTLFLTPSSQDDGATLICRARSQALPTGRDTAVTLS 230

  Fly   240 IVDGEHP------AAMHTGNNGN------STASQPPV 264
            :   ::|      |...|...|.      ...:||||
  Rat   231 L---QYPPMVTLSAEPQTAQEGEKVTFLCQATAQPPV 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	23/88 (26%)
		V-set	52..143	CDD:284989	24/99 (24%)
		IG_like	153..238	CDD:214653	24/90 (27%)
		ig	153..232	CDD:278476	20/80 (25%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	24/101 (24%)
		Ig strand A'	40..44	CDD:409353	0/3 (0%)
		Ig strand B	48..57	CDD:409353	3/11 (27%)
		Ig strand C	62..66	CDD:409353	2/3 (67%)
		Ig strand D	75..85	CDD:409353	5/12 (42%)
		Ig strand E	88..100	CDD:409353	3/18 (17%)
		Ig strand F	107..115	CDD:409353	4/7 (57%)
		Ig strand G	117..127	CDD:409353	1/9 (11%)
		Ig	133..231	CDD:416386	26/99 (26%)
		Ig strand A	134..137	CDD:409353	0/2 (0%)
		Ig strand A'	140..144	CDD:409353	1/3 (33%)
		Ig strand B	151..158	CDD:409353	4/6 (67%)
		Ig strand C	164..169	CDD:409353	1/4 (25%)
		Ig strand C'	172..174	CDD:409353	0/1 (0%)
		Ig strand D	177..184	CDD:409353	0/6 (0%)
		Ig strand E	191..199	CDD:409353	2/7 (29%)
		Ig strand F	208..216	CDD:409353	1/7 (14%)
		Ig strand G	222..228	CDD:409353	1/5 (20%)
		Ig_3	234..303	CDD:404760	8/31 (26%)
		Ig strand B	252..256	CDD:409353	0/3 (0%)
		Ig strand C	266..270	CDD:409353
		Ig strand E	283..286	CDD:409353
		Ig strand F	292..301	CDD:409353
		Ig strand G	309..312	CDD:409353
		Ig	326..403	CDD:416386
		Ig strand A'	327..332	CDD:409353
		Ig strand B	335..344	CDD:409353
		Ig strand C	350..354	CDD:409353
		Ig strand C'	357..359	CDD:409353
		Ig strand D	362..365	CDD:409353
		Ig strand E	366..371	CDD:409353
		Ig strand F	379..387	CDD:409353
		Ig strand G	393..403	CDD:409353
		Ig	405..509	CDD:416386
		Ig strand A	406..410	CDD:409353
		Ig strand A'	412..415	CDD:409353
		Ig strand B	423..430	CDD:409353
		Ig strand C	437..442	CDD:409353
		Ig strand C'	444..447	CDD:409353
		Ig strand D	455..462	CDD:409353
		Ig strand E	472..479	CDD:409353
		Ig strand F	490..497	CDD:409353
		Ig strand G	500..507	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900