DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Muc12Ea and MUC6

DIOPT Version :9

Sequence 1:NP_001368944.1 Gene:Muc12Ea / 32384 FlyBaseID:FBgn0052602 Length:3321 Species:Drosophila melanogaster
Sequence 2:NP_005952.2 Gene:MUC6 / 4588 HGNCID:7517 Length:2439 Species:Homo sapiens


Alignment Length:1340 Identity:385/1340 - (28%)
Similarity:530/1340 - (39%) Gaps:232/1340 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   984 PTTLKPTEGTSAKPTTLK-PTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTSAKPTTLKPTDGTTA 1047
            |||.:|       |||.: ||.|  ::||.:.|..|||   ||:.....|...|:    ::.|.|
Human  1199 PTTPQP-------PTTPQLPTTG--SRPTQVWPMTGTS---TTIGLLSSTGPSPS----SNHTPA 1247

  Fly  1048 KP--TTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPT--- 1107
            .|  |.|.|...||:|||.   :.|...:|||....:.||..|.| .....|..|||..:.|   
Human  1248 SPTQTPLLPATLTSSKPTA---SSGEPPRPTTAVTPQATSGLPPT-ATLRSTATKPTVTQATTRA 1308

  Fly  1108 EGTTAKPTTLKPTEGTTAKPTTLKPTEGTS-AKPTTLKPTE----GTTAKPTT-LKPTEGTTAKP 1166
            ..:||.|.|....:.||....|| ||..|| ..||..|.|.    ||||..|| .:||..:|..|
Human  1309 TASTASPATTSTAQSTTRTTMTL-PTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGP 1372

  Fly  1167 TTLKPTEGTSAKPTTLKPTEGTTAKPTTLNQLRERVPSQHFEPTEGTTAKPTTLKPTEGTTAKPT 1231
            ||  |..|...:||.   ||.|..:.|                ||.||.:      |..||..| 
Human  1373 TT--PQPGQPTRPTA---TETTQTRTT----------------TEYTTPQ------TPHTTHSP- 1409

  Fly  1232 TLKPTKGTTAKSTTLKPTEGTSAKPTTLKPTEG--TTAKPTTLKPTEGTSAKPTT---LKPTEG- 1290
               ||.|:...||  .|...||...||..||..  .|..||.:.|...:...|:|   :.||.. 
Human  1410 ---PTAGSPVPST--GPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQ 1469

  Fly  1291 -TTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTE 1354
             .|:......|| ||...|||||.|..|...|.....|.||:...::.    .|:..||:|....
Human  1470 MATSASNHSAPT-GTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSF----STNKTPTSLHSHT 1529

  Fly  1355 GTTAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLNAKP 1419
            .:|..| .:.||..||..|   .||...|..|.. .....||::|    |...||..|.|.::..
Human  1530 SSTHHP-EVTPTSTTTITP---NPTSTRTRTPVA-HTNSATSSRP----PPPFTTHSPPTGSSPF 1585

  Fly  1420 TTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAQPTT---LKPTEGTT 1481
            ::..|...|:.|.||..||           |:...|..||.:.|...:...|:|   :.||....
Human  1586 SSTGPMTATSFKTTTTYPT-----------PSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQM 1639

  Fly  1482 AKPTTL--KPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEG 1544
            |...::  .|| ||...|||||.|..|...||....|.|||...::|     .|||.:|     .
Human  1640 ATSASIHSMPT-GTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSL-----NTAKTST-----S 1693

  Fly  1545 TSAQPTTLKPTEGTSAQSTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPT-- 1607
            ..:..::....|.||..:|.:.|...:|..|.....|.|||...::....:.:|:..:....|  
Human  1694 LHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHH 1758

  Fly  1608 -EGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTSAKPTTLKP 1671
             |.||...|::.|...:|.   |..|...||:..::..||..|:..|.|     ||:...:| .|
Human  1759 PEVTSTSTTSITPNHTSTG---TRTPVAHTTSATSSRLPTPFTTHSPPT-----GTTPISST-GP 1814

  Fly  1672 TEGTSAKPTTLKPTEGTSAQPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTDGTTAKPTTLKP 1736
            ...||.:.||..|   |.:.|.|..||...|...:.:.|:..|...||   .|...|:......|
Human  1815 VTATSFQTTTTYP---TPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPT---HTQMATSASIHSMP 1873

  Fly  1737 TEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKP 1801
            | ||...|||:|.|..|...|.....|.|||..|::.     :|||.:|..|...:|.....:.|
Human  1874 T-GTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSF-----STAKTSTSLPYHTSSTHHPEVTP 1932

  Fly  1802 TERTSAQPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKP 1866
            |..|:..|   |.|...|..|.    ...|||..:.| ||..||..|.|     |:|...:| .|
Human  1933 TSTTNITP---KHTSTGTRTPV----AHTTSASSSRL-PTPFTTHSPPT-----GSSPFSST-GP 1983

  Fly  1867 TEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTDGTTAKPTT---LKPTEGTSAKPTT 1928
            ...|:.:.||..||           |:...|..||.:.|...:...|:|   :..|....|...:
Human  1984 MTATSFQTTTTYPT-----------PSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSAS 2037

  Fly  1929 LKPT-EGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSANAQPTTLKPTEGTTAK 1992
            :..| .||...|||||.|..|...|.....|.||:...::......:|:....::..|...::..
Human  2038 IHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRP 2102

  Fly  1993 PTTLKPTKGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAK 2057
            |         |:..||..|...:...|.:......::..|:...|:..:|..|:       :.:.
Human  2103 P---------SSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPS-------SHSS 2151

  Fly  2058 PTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAK 2122
            |.|..|:.|||:...: .|...||.       :.|:.:..:|...|...:|.|  |.|:  :.|.
Human  2152 PQTSSPSVGTSSSFVS-APVHSTTL-------SSGSHSSLSTHPTTASVSASP--LFPS--SPAA 2204

  Fly  2123 PTTLKPT-EGTTAKPTTLKPTEGTSAKPTSLKPTEGTTAKPTTLKPT----EGTTAKPTTLKPTD 2182
            .||::.| ..|.:.|.||          ::|.|....|..||   |:    ..|.|.|:|.:.|.
Human  2205 STTIRATLPHTISSPFTL----------SALLPISTVTVSPT---PSSHLASSTIAFPSTPRTTA 2256

  Fly  2183 GTSAKPTTLKPTEGTSAQPTTLKPTEGTTAKPTT--LKPTEGTTAKPTTLKPTEGTSAQPTTLKP 2245
            .|...|       ..|:|.||.:.|..||..||:  :..|.|.|..||: ..|..|:..|     
Human  2257 STHTAP-------AFSSQSTTSRSTSLTTRVPTSGFVSLTSGVTGIPTS-PVTNLTTRHP----- 2308

  Fly  2246 TEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPT 2285
              |.|..|||...|...:|..:|  |.....:...|..||
Human  2309 --GPTLSPTTRFLTSSLTAHGST--PASAPVSSLGTPTPT 2344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc12EaNP_001368944.1 PHA03247 <175..670 CDD:223021
PHA03247 <659..1197 CDD:223021 80/224 (36%)
PHA03247 <1049..1651 CDD:223021 190/627 (30%)
PHA03247 <1723..2186 CDD:223021 122/471 (26%)
PHA03247 <2110..2706 CDD:223021 53/183 (29%)
MUC6NP_005952.2 VWD 40..192 CDD:214566
C8 228..297 CDD:285899
TIL 302..357 CDD:280072
VWC_out 359..>403 CDD:214565
VWD 386..549 CDD:214566
C8 588..660 CDD:285899
TIL 664..721 CDD:280072
TIL 782..827 CDD:280072
VWC 829..886 CDD:302663
VWD 868..1017 CDD:278521
C8 1057..1127 CDD:285899
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1455 101/306 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1471..1626 51/179 (28%)
1, truncated 1561..1738 58/202 (29%)
Approximate repeats 1607..1953 110/384 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1642..1834 61/214 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1983 43/134 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2033..2077 15/43 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2090..2196 24/129 (19%)
PHA03255 2188..>2343 CDD:165513 53/188 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2233..2278 15/54 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2323..2348 6/24 (25%)
CT 2351..2434 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.