DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc12Ea and Y46B2A.3

DIOPT Version :9

Sequence 1:	NP_001368944.1	Gene:	Muc12Ea / 32384	FlyBaseID:	FBgn0052602	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	NP_493835.1	Gene:	Y46B2A.3 / 189942	WormBaseID:	WBGene00021578	Length:	1145	Species:	Caenorhabditis elegans

Alignment Length:	920	Identity:	307/920 - (33%)
Similarity:	396/920 - (43%)	Gaps:	134/920 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 EGTSAKPTTLK---------PTAGTTAKPTTLK---PTEGTSAKPT----TLKP---TEGTTAKP 464
            |..|.||..:.         .|.|||.....:|   .|.|.:.:||    |::.   |.|.|..|
Worm   156 ESQSDKPNNVNMVCCSPWKVSTRGTTNTNRNIKAHETTRGFTQRPTAAGWTIRANGITRGQTRVP 220

  Fly   465 -TTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTTAK 528
             ||.:||.    :|||...|.|  |..||...:.|.|.:|||.....|  |..||...:.|.|.:
Worm   221 GTTREPTH----RPTTAGWTNG--ANGTTRDTSRGFTQRPTTAGWRNG--ANGTTRDTSRGFTQR 277

  Fly   529 PTTLKPTEGTSAQPTTLKPTKGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAK 593
            |||.....|  |..||:..::..|.:|||...|.|  |..||:..:.|.|.:|||...|.|  |.
Worm   278 PTTAGWRNG--ANGTTIDTSREFTQRPTTAGWTNG--ANGTTIDTSRGFTQRPTTAGWTNG--AN 336

  Fly   594 PTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTKGTTAKPTTLKPTEGTSAKPTTLKPTDGTTAK 658
            .||:..:.|.|.:|||...|.|  |..||:..::..|.:|||...|.|  |..||:..:.|.|.:
Worm   337 GTTIDTSRGPTHRPTTAGWTNG--ANGTTIDTSREFTQRPTTAGWTNG--ANGTTIDTSRGPTHR 397

  Fly   659 PTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTDGTTAKPTTLKLTEGTSAK 723
            |||.....|  |..||...:.|.|.:|||.....|  |..||:..:...|.:|||...|.|  |.
Worm   398 PTTAGWRNG--ANGTTRDTSRGFTQRPTTAGWRNG--ANGTTIDTSREFTQRPTTAGWTNG--AN 456

  Fly   724 PTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTKGTTAK 788
            .||:..:.|.|.:|||...|.|  |..||...:.|.|.:||....|.|  |..||:..::|.|.:
Worm   457 GTTIDTSRGFTQRPTTAGWTNG--ANGTTSGTSRGFTQRPTIAGWTNG--ANGTTIDTSRGFTQR 517

  Fly   789 PTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAK 853
            |||...|.|  |..||...:.|.|.:||....|.|.:.      .|.|.|..|.|   |.|.|.:
Worm   518 PTTAGWTNG--ANGTTSGTSRGFTQRPTIAGWTNGANG------ITRGQTRVPGT---TRGPTHR 571

  Fly   854 PTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTDGTTAK 918
            |||...|:|  |..||...:.|.:.:|||...|.|  |..||...:.|.|.:||....|:|  |.
Worm   572 PTTAGWTNG--ANGTTRDTSRGFTQRPTTAGWTNG--ANGTTSGTSRGFTQRPTIAGWTNG--AN 630

  Fly   919 PTTLKPTEGTSAKPTTLKPTDGTTAKSTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAK 983
            .||:..:.|.:.:|||...|:|  |..||...:.|.:.:||....|.|  |..||...:.|.|.:
Worm   631 GTTIDTSRGFTQRPTTAGWTNG--ANGTTSGTSRGFTQRPTIAGWTNG--ANGTTSGTSRGFTQR 691

  Fly   984 PTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTSAKPTTLKPTDGTTAK 1048
            |||...|.|  |..||...:.|.|.:|||...|.|.:.      .|.|||.         |.|.:
Worm   692 PTTAGWTNG--ANGTTSGTSRGFTQRPTTAGWTNGANG------TTSGTSR---------GFTQR 739

  Fly  1049 PTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAK 1113
            ||....|.|.:.      .|.|.|..|.|                |.|.|.:|||...|.|  |.
Worm   740 PTIAGWTNGANG------ITRGQTRVPGT----------------TRGPTHRPTTAGWTNG--AN 780

  Fly  1114 PTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAK 1178
            .||...:.|.|.:|||...|.|  |..||...:.|.|.:||....|.|  |..||...:.|.:.:
Worm   781 GTTRDTSRGFTQRPTTAGWTNG--ANGTTSGTSRGFTQRPTIAGWTNG--ANGTTSGTSRGFTQR 841

  Fly  1179 PTTLKPTEGTTAKPTTLNQLRERVPSQHFEPTEGTTAKPTTLKPTEGTTAKPTTLKPTKGTTAKS 1243
            ||    ..|.|.:...:.:.:.|||.    .|.|.|.:|||...|.|  |..||...::|.|.:.
Worm   842 PT----AAGWTIRANGITRGQTRVPG----TTRGPTHRPTTAGWTNG--ANGTTRDTSRGFTRRP 896

  Fly  1244 TTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKP 1308
            ||...|.|  |..||...:.|.|.:||....|.|  |..||...:.|...:||....|.|...
Worm   897 TTAGWTNG--ANGTTSGTSRGFTQRPTAAGWTNG--ANGTTSGTSRGFAQRPTAAGWTNGANG-- 955

  Fly  1309 TTLKPTEGTS 1318
                .|.|||
Worm   956 ----TTSGTS 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc12Ea	NP_001368944.1	PHA03247	<175..670	CDD:223021	92/270 (34%)
		PHA03247	<659..1197	CDD:223021	178/537 (33%)
		PHA03247	<1049..1651	CDD:223021	85/270 (31%)
		PHA03247	<1723..2186	CDD:223021
		PHA03247	<2110..2706	CDD:223021
Y46B2A.3	NP_493835.1	VMO-I	34..170	CDD:238135	4/13 (31%)
Y46B2A.3	NP_493835.1	VOMI	34..170	CDD:281719	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16987
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940