DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc12Ea and H02F09.3

DIOPT Version :9

Sequence 1:	NP_001368944.1	Gene:	Muc12Ea / 32384	FlyBaseID:	FBgn0052602	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	NP_508295.1	Gene:	H02F09.3 / 186667	WormBaseID:	WBGene00019146	Length:	1275	Species:	Caenorhabditis elegans

Alignment Length:	1379	Identity:	329/1379 - (23%)
Similarity:	554/1379 - (40%)	Gaps:	216/1379 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFVICLLVASTAAFTMFGPHIRIVPGQKPNEIVLHFRNPCNNKTSTTTLKPPPPPCPSHPTTPAC 67
            ::::.:|..|.|  .:.|..:.||...:||:..     |.:.:..|.:|      |.|:......
Worm    11 IYLVFILAVSAA--LVAGLILTIVLVSRPNKAA-----PFDGRVITVSL------CNSNSEPQIS 62

  Fly    68 EHRITSPAPTKPHCPHATATPHNCGHDTTSSSRATTPKPTLETTIGTTFKTTQITTRGPTTQK-- 130
            ..|....|.|  .|.. .|..:...:..|||  |......|.|..||:.||..:|.:....|.
Worm    63 SLRFKRDANT--DCSF-NANKNQLRNFLTSS--AEDANFILTTYSGTSTKTEPLTKQLALDQLEA 122

  Fly   131 -PTEGTSA----------QPTTLKPTEGTTAKP---------TTLKPTEGTTAKPTT-------- 167
             ..:|:||          .|:....|:.....|         ..:|..:....|..|
Worm   123 IKADGSSAVKQSSAIESYDPSAYSNTDLVFFTPCQTNYDGIEDDIKNVQTAINKVITKTFVIVSL 187

  Fly   168 -LKPTE-----GTSAK--PTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTE 224
             |..|:     |.:|.  |||  |||..:.|...:.....|...|.|......|||..|:..|..
Worm   188 SLNSTDMNSRYGEAAHNIPTT--PTEDISNKINNILNIGTTQTPPVTTSTMATTTANVTSAAPNT 250

  Fly   225 GTT--AKPTTL--KPTEGTTAKPTTLKPTEGTSAKPTTL--KPTEGTTAKPTTLKPTEGTSAKPT 283
            ..|  ..|||:  .|:...|:..||:.....|...|||:  .||...|...|.:.....|.:...
Worm   251 TVTISTSPTTVVTVPSTAQTSSTTTVTVPTTTVTGPTTVVTVPTTVVTIPSTVVTSPITTPSTVV 315

  Fly   284 TLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTL---KPTEGTTAKPTTLKPTEGTSA 345
            |:..|..|.......||:...||..|.:........||.|:   .||..||  |||:..|..|..
Worm   316 TVPSTVVTVPSTAVTKPSTVVTAPSTVVTVPSTVVTKPNTVVTSSPTVATT--PTTVVTTPSTVV 378

  Fly   346 K--------PTTL--KPTEGTTAKPT--TLKPTEGTSAKPTTLKPTEGTSAKPTTLKPTEGTSAK 398
            .        |||:  .|:...||..|  |:..|..||.......||.|.|:..|.     |||..
Worm   379 TVPSTVVTVPTTVVTNPSTVVTAPSTVVTVPTTVMTSRSTVITTPTTGGSSPSTA-----GTSLA 438

  Fly   399 PT--TLKPTEGTSAKPTTLKPTEGTSAKPTTL------KPTAGTTAKPT--TLKPTEGT--SAKP 451
            .|  |.:.:.|:|:.|.   |::.||...::|      ..|||.|:..|  :.|||.||  |:.|
Worm   439 STAVTTETSIGSSSTPL---PSQSTSLSMSSLSTYTPSSSTAGATSPATQQSTKPTIGTSMSSGP 500

  Fly   452 TTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQP 516
            ||:.|  |.:.:.|.|   :.:|...||:....|:|.......|...|....|.:....|::...
Worm   501 TTVAP--GASTESTVL---QSSTPSGTTVTLPSGSSTATAGTSPQASTVTTVTDISTVSGSTVTS 560

  Fly   517 TTLK---PTEGTTAKPTTLKPTEGTSAQPTTLKPTKGTTAKPTTLKPTEGTSAKPTTLKPTEGTT 578
            .|.:   .||..|:..:::......|:||:|..|....::..:||..:.|::|.|.|.:.:..:|
Worm   561 QTAESSLSTESPTSAGSSISTVSTVSSQPSTYIPVSSASSIYSTLSGSTGSTASPGTTESSGSST 625

  Fly   579 AKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTKGTTAKPTTLKPTEGTS 643
            :.|:|:   .|:||...|     |:|.       ||.::        ..|:|...|....||.|.
Worm   626 SGPSTI---SGSSASTVT-----GSTV-------TEAST--------ISGSTESSTIPGSTESTV 667

  Fly   644 AKPTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTDGTT 708
            ::.:|:..:..:|...:    ||.|||..:|:..:.|:|...:            :|:..:.|:|
Worm   668 SEASTVSGSSVSTVSGS----TESTSAGASTVSGSTGSTVSDS------------STISDSTGST 716

  Fly   709 AKPTTLKLTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTS 773
            ..|.:.:.|. |.:..:|:..:.|:|.              |:|:..:.|:|..|.:   ||.|.
Worm   717 NAPGSTESTV-TGSSVSTVSGSTGSTG--------------PSTMSASTGSTNTPGS---TESTI 763

  Fly   774 AQPTTLKPTKGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTT 838
            ...:|:..:.|:|........|:.::...:|:..:..:|...:|.....|:|    .:..:.|:|
Worm   764 TDGSTVSGSTGSTGSTNNPGSTDSSTTGISTVSGSSLSTISGSTGSTVSGSS----DMTVSTGST 824

  Fly   839 AKPTTLKPTEGTTAKPTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTT 903
            :.|.:   ||.|.:..:|:.|:.|::.:.:    |.|:|....:...:..||.:.|..:.:..|.
Worm   825 SSPGS---TESTVSGASTMSPSTGSSVETS----TSGSSVSTVSQSTSSSTTGQSTVSESSVSTV 882

  Fly   904 AKPTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTDGTTAKSTTLKPTEGTSAKPTTLKPT---- 964
            :..:|:..:.|:|           |:.:.|....|..|...|:|:..:.|::..|.:.:.|
Worm   883 SSESTISQSTGST-----------TTGESTVFGSTGSTATGSSTMSASTGSTDTPGSTESTITGS 936

  Fly   965 ----EGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTL--KPTEGTTAKPTTLKPTEGTSAQP 1023
                |.|.:..|....|||:|...:|: .|.|.|...|..  ....|:|....|.:.|...|.:.
Worm   937 TVTGESTVSGSTGSTITEGSTISESTM-TTVGVSTGSTITGESTVSGSTRSTVTGESTVSGSTES 1000

  Fly  1024 TTLKPTEGTSAKPTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKP 1088
            |....||.|...|:|:   .|:|....|.:.|...|...|:...|..:|...:|:..:..::...
Worm  1001 TVSGSTESTPTVPSTV---SGSTGSTVTGESTVSGSTASTSSGSTGSSTEAGSTVSGSSASTVTS 1062

  Fly  1089 TTLKPTEG-TTAKPTTLKPTEGTTAKPTTLKPT-EGTTAKPTTLKPTEGTSAKPTTLKPTEGTTA 1151
            :|...|.| :|...:|:....|:|....|.:.| .|:|....|.:.|...|:..|....|..|..
Worm  1063 STGSSTSGESTVSGSTVSTVSGSTGSTITGESTVSGSTESTVTAESTVSGSSVSTVSGNTGSTIT 1127

  Fly  1152 KPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTA---KPTTLNQLRERVPSQHFEPTEGT 1213
            ..:|:..:.|:|.:.|.|:.:..|.:..|....|:|:||   ..:|::...|...|.....:.|:
Worm  1128 GESTVSGSTGSTGESTILESSVSTVSVSTGSTITDGSTASRSSVSTVSASTESTVSGGSSASIGS 1192

  Fly  1214 TAKPTTLKPTEGTTAKPTTLKPTKGTTAKSTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGT 1278
            |..|.:   || :|...:|:..:.|:|..||.   :.||.:..|:  .:.|:|...::|..:...
Worm  1193 TNTPDS---TE-STISGSTISGSTGSTESSTM---SAGTGSTETS--TSGGSTVSGSSLSTSSTE 1248

  Fly  1279 SAKPTTLKPTEGTT 1292
            |:..::.:|...:|
Worm  1249 SSGSSSTQPPSTST 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc12Ea	NP_001368944.1	PHA03247	<175..670	CDD:223021	145/532 (27%)
		PHA03247	<659..1197	CDD:223021	123/552 (22%)
		PHA03247	<1049..1651	CDD:223021	58/249 (23%)
		PHA03247	<1723..2186	CDD:223021
		PHA03247	<2110..2706	CDD:223021
H02F09.3	NP_508295.1	PLN02217	<506..609	CDD:215130	23/105 (22%)
H02F09.3	NP_508295.1	PLN02217	<923..1025	CDD:215130	27/105 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000