DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc12Ea and rp1l1a

DIOPT Version :9

Sequence 1:	NP_001368944.1	Gene:	Muc12Ea / 32384	FlyBaseID:	FBgn0052602	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	XP_005169865.1	Gene:	rp1l1a / 101882236	ZFINID:	ZDB-GENE-120711-1	Length:	2394	Species:	Danio rerio

Alignment Length:	1691	Identity:	314/1691 - (18%)
Similarity:	497/1691 - (29%)	Gaps:	342/1691 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1517 EGTSAKPTTLKPTEGTTAK-PTTLKPTEGTSAQPTTLKPTEGTSAQSTTLKPTEG----TTAKPT 1576
            ||.|.|..|   ....:|| ...:...:.|.|...|........:|...:.|...    :.|..|
Zfish   842 EGESVKERT---KSAMSAKSDCIISQRDPTPALVLTETDNAEEESQERAVSPMSAHSNLSAASKT 903

  Fly  1577 TLKPTEGTSAKPTTLKPTEGTTAKPTTLK--------PTEGTSAKPTTLKPTEGTTAKPTTLKPT 1633
            :.|...|.|.|..|.:.......:...||        |....|..||.   ::....:.|.| |.
Zfish   904 SYKSISGHSEKAKTPRMCSPNDVEEVPLKLINSQGDEPESAASPNPTL---SDNHNEQDTEL-PH 964

  Fly  1634 EGTTAKPTTLKPTEGTSAKPT-----TLKPTEGTSAKPTTL--KPTEGTSAKPTTLKPTEGTSAQ 1691
            |..:|...:.|..: :|..|:     ::|..|.....|..|  ..||....:|.       ::..
Zfish   965 EVRSASAMSNKSNQ-SSQHPSKDSKRSVKSCELQGKSPDVLCELKTEERQCRPL-------SNCS 1021

  Fly  1692 PTTLKPTEGTSAKPTTLKPTE----GTTAKPTTLK------------PTDGTTAKPTTLKPTEGT 1740
            .|::|..|.:.......|..|    ..:||....|            |....|:......|.|
Zfish  1022 KTSVKSNESSKHSQAEAKSQERVPSAMSAKTNASKRSCRSCRANHNIPETTVTSVLNDATPDE-- 1084

  Fly  1741 SAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTERT 1805
            .|.||. |....|:....|.:.:...|.: :....|:.||....|:          |:..|.::.
Zfish  1085 CATPTN-KSKRATSPMSQTSEKSNACSER-SIKSETQKTTLNALTV----------TSPLPRKKQ 1137

  Fly  1806 SAQPTTLKPTEGTTAKPTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGT 1870
            |..|   :.|..:.:|.|..:...|.|......:                 .|.|...|..:.|
Zfish  1138 SPSP---RSTHNSKSKKTDSRAASGMSENSNVSR-----------------RSGKCNCLGSSNG- 1181

  Fly  1871 TAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTDGTTAKPTTLKPTEGTSAKPTTLKPTEGT 1935
            ..|....:..:..|..|..: |::.|..  ..:|.:|....:|  :.||...|......:..:|.
Zfish  1182 DLKEKLKEDAKDVSGFPDKI-PSDSTLI--NNIKSSDNQFDEP--VSPTSTASVSLGLGEDQKGD 1241

  Fly  1936 TAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSANAQPTTLKPTEGTTAKPT-TLKPT 1999
            .....:   |.|.|        .:|    ...|....|..|..:|.|..........|. .|.|.
Zfish  1242 DFDDLS---TSGMS--------EDG----GNRLHEVNGVDAEERPKTEASVNSHHKSPVQALLPV 1291

  Fly  2000 KGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPT 2064
            ...|.....||.::..:      :..|.....|:||..:...|..|:.|.|   .:||.|.:|..
Zfish  1292 SAESVMSAELKKSKSGS------QLNENNIRVPSTLSLSSSRSKSPSRLSP---GSAKNTAMKER 1347

  Fly  2065 EGTSAQPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKP-TEGTTAKPTTLKPTEGTSAKPTTLKP 2128
            :..:...|........::|.   :.:|..:.|.|.... .:.:.|...::|...|.|.:.|..:.
Zfish  1348 DCKAVNNTNHAERSEASSKH---EQSERAAGKVTPASEFLDSSKASECSVKSKNGQSIRETDKRS 1409

  Fly  2129 TEGT-------------------TAKPTTLKPTEGTSAKPTSLKPTEGTTAKPTTLKPTEGTTAK 2174
            ...:                   ..|......::..|.|..:.:|.....:..:...|.|....|
Zfish  1410 KHSSHCLEMNGLDINSNRDLDDGMVKSLKASTSDKRSVKNDASRPNSAGKSDISQSLPLEMPNKK 1474

  Fly  2175 PTTLKPTDGTS--------AKPTTLKPTEGTSAQPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLK 2231
            ..::|..|.:|        :....|:...| ||:|.:.......::|  .:...|..:.|.:..|
Zfish  1475 KASVKHPDSSSESVLSRALSAADLLREIVG-SARPVSRGSKSVASSK--NVDKVENKSQKSSRSK 1536

  Fly  2232 PTEGTSAQPTTLKPTEGTTAKPTTLK-------PTEG----TSAKPTTLKPTEGTTAK-----PT 2280
            |:..:......|.|:....|.||.:.       |..|    ...:.|..:..|..:.:     |.
Zfish  1537 PSHSSEHNTKELMPSCLPNASPTEVVNDWLRNIPIGGYVYEMDVEHTEREAGENASQRDKSEAPE 1601

  Fly  2281 TLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTDGTTAKPTTLKPTEGTSAK-- 2343
            ::...|..:..||.....:..|.........|....:...:.....|.|...:|:....:|.:
Zfish  1602 SIMEVEEPNENPTGENHVQQETNDVEIQACDEKAQLEMCEMDHNPKTLANQDSLQKQCDSSVQVM 1666

  Fly  2344 PTTLKPTEGTTAKPTTLKPTEGTSAKPTT-----------LKPTDGTTAKPTTL----------- 2386
            ...|.|....::....:.|..|.....:.           |..:|....|....
Zfish  1667 KVLLGPKLDRSSSLPEVSPVYGRKLSQSAQGLLDCLANLRLIDSDSKDEKHRKYNEVMMILQSLW 1731

  Fly  2387 --KPTEGTSAKPT----------TLKPTEGTTAKPTTLKPTEGTSAKPT--TLKPTEGTSAKPTT 2437
              ||.|....|..          .|:.:.|......:....:|...:.:  |:.|.|........
Zfish  1732 LQKPIEDEHIKQNAKVNQSEDEFNLRYSSGVDVNSGSTSSFKGEKIETSQGTIPPIEKQEISRND 1796

  Fly  2438 LKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTDGTTAKPTTLKPTEGTSAKPTT 2502
             |..|....|.|....:......|.|....|.|...|...:..|......|    .|..|:...
Zfish  1797 -KDDEEDEVKFTECLDSSKIIPDPVTPDIAERTQGSPVNTRQDDDQENDVT----QEDVSSSEN- 1855

  Fly  2503 LKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGT--SAQPTTLKPTERTSAQP 2565
             |.....|.:.|:.|.:...|   .|:|..|.|::         ||  |.|..||  |:|.|..|
Zfish  1856 -KNESDQTPQTTSYKSSGNES---YTMKSPENTSS---------GTPPSVQKATL--TKRVSQDP 1905

  Fly  2566 ------TTLKPTEGTTAKPTTLKPTEGTSAQPT--TLKPTERTSAQPTTLKP------TEGTTAK 2616
                  :.||..|    |...|..|:..:....  .|...|..:...:.||.      ......:
Zfish  1906 DPVWVLSLLKKLE----KQFMLHYTDAMAEFKVRWDLDDNEMLNTMISELKEEVHKRIQSSINRE 1966

  Fly  2617 PTTLKPTKGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAK 2681
            ...::...|...:|            |......|.|.......|.......|....:..|..||.
Zfish  1967 LQKIQSRTGRGPRP------------PGNALSRESTAQTEQRRKRLRVMRNKSILTRSDEDYTAS 2019

  Fly  2682 PTTLK---------PTDGTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLK--PTEGTSAKPT 2735
            .|...         |.|....|....:..:...|........|....|...:|  |.|     |:
Zfish  2020 GTENSDQRSDDEYCPCDACIKKKLASRAAQRAQALSFAPVIMEFDLRKILQMKKDPVE-----PS 2079

  Fly  2736 TLKPTEGTTA--KPTTLK-----------PTEGTSAKPTTLKPTEGTTAKPTTLKPTDGTTAKPT 2787
            ..||.|..||  ....|:           .|.|...|....:.|:            |...|...
Zfish  2080 QSKPEEQCTACQVENNLEVVHEEVEEVNDDTRGRDVKMADQEETD------------DADNAIDA 2132

  Fly  2788 TL----KPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTEGTSAKPTTLKPTEGTT 2848
            ||    |......|...:....:|...|          .|:|.  |...|.:.........||..
Zfish  2133 TLDSEKKDQNDEEANDKSDDVDDGQNEK----------EAEPA--KEEMGVNDTGDDENEEEGNL 2185

  Fly  2849 AKPTTLKPTEGTTAKPTTLKPTEGTSAKPT-TLKPTEGTTAKPTTLKPTEGT--SAKPTTLKPTE 2910
            .:....|  |..|.....::.::.|:.|.| :.:.||....:.|..:.||..  |.|..|.:.|:
Zfish  2186 VEEDMEK--EACTEHAPNIENSDSTAQKMTESAEETEAVDKQTTEDQSTEEVEESNKDDTPETTK 2248

  Fly  2911 GTTAKPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLK---------PTEGTSAKPTTLKPTEGTTA 2966
            |.|  ||..|..:|||   .|.:..|  |.|...:|         ..|..|:.......|:...|
Zfish  2249 GET--PTIEKNADGTS---DTGQDDE--TGKMPKVKIEMEVRESVEHEDKSSSVEEQNETDDALA 2306

  Fly  2967 KPTTLKPTEGTSAKPTTLKPTEGTTAKPTTLKPTEGTTAKPTTLKPTDGTTAKPTTLKPTEGTSA 3031
            |..|...||.....      .|..||: ..||..:.......:...:...|.:|...:|.|..:.
Zfish  2307 KQATKTSTESQQGS------MENCTAQ-AKLKDLQSFMESLESHGDSVVITKQPPYKEPHEAANQ 2364

  Fly  3032 K 3032
            |
Zfish  2365 K 2365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc12Ea	NP_001368944.1	PHA03247	<175..670	CDD:223021
		PHA03247	<659..1197	CDD:223021
		PHA03247	<1049..1651	CDD:223021	31/146 (21%)
		PHA03247	<1723..2186	CDD:223021	87/491 (18%)
		PHA03247	<2110..2706	CDD:223021	116/701 (17%)
rp1l1a	XP_005169865.1	DCX	41..119	CDD:176357
rp1l1a	XP_005169865.1	UBQ	164..239	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6373
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000