DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1461 and KYAT1

DIOPT Version :9

Sequence 1:	NP_001285238.1	Gene:	CG1461 / 32381	FlyBaseID:	FBgn0030558	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001274319.1	Gene:	KYAT1 / 883	HGNCID:	1564	Length:	516	Species:	Homo sapiens

Alignment Length:	517	Identity:	117/517 - (22%)
Similarity:	210/517 - (40%)	Gaps:	121/517 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PSEPESPAPVTPNCDVVDQALAELQLQSQDIRKQQDLVDTTATSSSSRKRSG-----WEIKGSKL 86
            |..|:||..|.....::....|:|.:|....:.      ..|....:|:..|     |
Human    61 PQGPQSPCEVPAAEGILRTGGAKLPIQGHPAKL------AMAKQLQARRLDGIDYNPW------- 112

  Fly    87 SLNTHNRIRNIVESLKIKPNPEKPMIPLSIGDPTTFGNLKAADETMKAVLHSLESGKY--NGYAS 149
                       ||.:|:.  .|..::.|..|    |.:....|..::|..|:: ||.:  |.|..
Human   113 -----------VEFVKLA--SEHDVVNLGQG----FPDFPPPDFAVEAFQHAV-SGDFMLNQYTK 159

  Fly   150 TQGHEIARKAVAKYSAHQRPDGEIDANE------VVLCSGCSSALEYCILALADRGQNVLVPRPG 208
            |.|:....|.:|.:.      ||:...|      |::..|...||.....||.|.|..|::..|.
Human   160 TFGYPPLTKILASFF------GELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPF 218

  Fly   209 FCLY---YTLAQGLDI-------EVRYYDLLPDQQWRADLVQLESLIDENTAALLINNPSNPCGS 263
            |..|   ..:|.|..:       .::..:|.....|:.|.::|.......|.||::|.|:||.|.
Human   219 FDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGK 283

  Fly   264 VFDEKHLRELIAICERHYLPIIADEIYEHFVFPGSKHLAVSSLTTEVP-----VLSCGGLTKRFL 323
            ||..:.|..:.::|::|.:..|.||:|:..|:.|.:|::::||    |     .|:.|...|.|.
Human   284 VFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASL----PGMWERTLTIGSAGKTFS 344

  Fly   324 VPGWRMGWIIVHDRKNRLRDAIVGLKNMCGRILGSNTII------QGALPD------ILTKTPQS 376
            ..||::||::..|..         :|::  |.:..|::.      |.|:.:      :|.:.|.|
Human   345 ATGWKVGWVLGPDHI---------MKHL--RTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSS 398

  Fly   377 YFDGVIDVLHSNAMLAYK--MLKQVR--GLDPVMPNGAMYMMIGVS--IERFPEFKD------DT 429
            ||     |....||...:  |::.::  ||.|::|.|:.:::..:|  ..:.|:...      |.
Human   399 YF-----VQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDR 458

  Fly   430 HFVQEMVNEQSVFCLPGSCF-------EYPGYVRIVLTVPGAMIEEACSRIAEFCDRHYKKE 484
            .||:.|:..:.:..:|.|.|       .:..|:|.......|.::....::     |.:|.|
Human   459 RFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKL-----RKWKVE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1461	NP_001285238.1	tyr_amTase_E	79..481	CDD:273529	104/455 (23%)
CG1461	NP_001285238.1	AAT_like	112..475	CDD:99734	98/416 (24%)
KYAT1	NP_001274319.1	Aminotran_1_2	118..512	CDD:332562	100/431 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810