DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1461 and ACCSL

DIOPT Version :9

Sequence 1:	NP_001285238.1	Gene:	CG1461 / 32381	FlyBaseID:	FBgn0030558	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001027025.2	Gene:	ACCSL / 390110	HGNCID:	34391	Length:	568	Species:	Homo sapiens

Alignment Length:	397	Identity:	92/397 - (23%)
Similarity:	151/397 - (38%)	Gaps:	100/397 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 DPTTFG--NLKAADE--TMKAVLHSLESGKYN-------GYASTQGHEIARKAVAKYSAHQ-RPD 170
            |..|.|  ||..::.  .|..:...|:....|       .|...:|....|:.||::..:. |..
Human   164 DKNTLGFINLGTSENKLCMDLMTERLQESDMNCIEDTLLQYPDWRGQPFLREEVARFLTYYCRAP 228

  Fly   171 GEIDANEVVLCSGCSSALEYCILA--LADRGQNVLVPRPGFCLYYTLAQGLDIEVRYY---DLLP 230
            ..:|...||:.:||.|.  :|.||  |.|.|:..|||.|    :|   .|.....|.|   :|:|
Human   229 TRLDPENVVVLNGCCSV--FCALAMVLCDPGEAFLVPAP----FY---GGFAFSSRLYAKVELIP 284

  Fly   231 DQQWRADLVQLES------------LIDENTAALL-------------INNPSNPCGSVFDEKHL 270
                    |.|||            .:|:...|||             :.||.||.|.::....|
Human   285 --------VHLESEVTVTNTHPFQLTVDKLEEALLEARLEGKKVRGLVLINPQNPLGDIYSPDSL 341

  Fly   271 RELIAICERHYLPIIADEIYEHFVFPGS----KHLAVSSLTTEVPVLSCGGLTKRFLVPGWRMGW 331
            .:.:...:|:.|.:|.||||...||..|    ..|::.||..........|.:|.|.:.|:|.|.
Human   342 MKYLEFAKRYNLHVIIDEIYMLSVFDESITFHSILSMKSLPDSNRTHVIWGTSKDFGISGFRFGA 406

  Fly   332 IIVHDRKNRLRDAIVGLKNMCGRILGSNTIIQGALPDILTKTPQSYFDGVIDVLHSNAML---AY 393
            :..|:::      :....:..|.:...:.|.|..|..:|..|  .:.|.|  .|.:|...   |:
Human   407 LYTHNKE------VASAVSAFGYLHSISGITQHKLCQLLQNT--EWIDKV--YLPTNCYRLREAH 461

  Fly   394 KML-KQVRGLDPVMPNGAMYMMIGVSIERFPEFKDDTHFVQE--------------------MVN 437
            |.: .:::.|:....|.:..:.:.:::::   :.|...|.:|                    |..
Human   462 KYITAELKALEIPFHNRSSGLYVWINLKK---YLDPCTFEEERLLYCRFLDNKLLLSRGKTYMCK 523

  Fly   438 EQSVFCL 444
            |...|||
Human   524 EPGWFCL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1461	NP_001285238.1	tyr_amTase_E	79..481	CDD:273529	92/397 (23%)
CG1461	NP_001285238.1	AAT_like	112..475	CDD:99734	92/397 (23%)
ACCSL	NP_001027025.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PLN02607	150..561	CDD:215327	92/397 (23%)
		AAT_like	171..546	CDD:99734	89/390 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810