DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1461 and Tat

DIOPT Version :9

Sequence 1:	NP_001285238.1	Gene:	CG1461 / 32381	FlyBaseID:	FBgn0030558	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_666326.1	Gene:	Tat / 234724	MGIID:	98487	Length:	454	Species:	Mus musculus

Alignment Length:	427	Identity:	218/427 - (51%)
Similarity:	303/427 - (70%)	Gaps:	14/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KRSGWEIKGSKLSLNTHNRIRNIVESLKIKPNPEKPMIPLSIGDPTTFGNLKAADETMKAVLHSL 139
            :::.|.::.|.:|..|.|.||.||:::|:||||.|.:|.|||||||.||||....|..:|:..:|
Mouse    37 RKARWNVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDAL 101

  Fly   140 ESGKYNGYASTQGHEIARKAVAKYSAHQRPDGEIDANEVVLCSGCSSALEYCILALADRGQNVLV 204
            :||||||||.:.|:..:|:.||.|  :..|:..::|.:|:|.||||.|:|.|:..||:.|||:|:
Mouse   102 DSGKYNGYAPSIGYLSSREEVASY--YHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILI 164

  Fly   205 PRPGFCLYYTLAQGLDIEVRYYDLLPDQQWRADLVQLESLIDENTAALLINNPSNPCGSVFDEKH 269
            |||||.||.|||:.:.|||:.|:|||::.|..||.||||||||.||.|::|||||||||||.::|
Mouse   165 PRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRH 229

  Fly   270 LRELIAICERHYLPIIADEIYEHFVFPGSKHLAVSSLTTEVPVLSCGGLTKRFLVPGWRMGWIIV 334
            |::::|:.||..:||:|||||...||...|:..:::|:|.||:||||||.||:||||||:|||::
Mouse   230 LQKILAVAERQCVPILADEIYGDMVFSDCKYEPMATLSTNVPILSCGGLAKRWLVPGWRLGWILI 294

  Fly   335 HDRK----NRLRDAIVGLKNMCGRILGSNTIIQGALPDILTKTPQSYFDGVIDVLHSNAMLAYKM 395
            |||:    |.:||.:|.|..   ||||..||:||||..||.:|||.::...:..|.|||.|.|..
Mouse   295 HDRRDIFGNEIRDGLVKLSQ---RILGPCTIVQGALKSILQRTPQEFYQDTLSFLKSNADLCYGA 356

  Fly   396 LKQVRGLDPVMPNGAMYMMIGVSIERFPEFKDDTHFVQEMVNEQSVFCLPGSCFEYPGYVRIVLT 460
            |..:.||.||.|:||||:|:|:.:|.||||::|..|.:.::.||||.|||.:|||||.:.|:|:|
Mouse   357 LSAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLIAEQSVHCLPATCFEYPNFFRVVIT 421

  Fly   461 VPGAMIEEACSRIAEFCDRHYKKESRNFIEHGLLDCD 497
            ||..|:.||||||.|||::||     :..|....:||
Mouse   422 VPEVMMLEACSRIQEFCEQHY-----HCAEGSQEECD 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1461	NP_001285238.1	tyr_amTase_E	79..481	CDD:273529	213/405 (53%)
CG1461	NP_001285238.1	AAT_like	112..475	CDD:99734	195/366 (53%)
Tat	NP_666326.1	TAT_ubiq	1..40	CDD:369474	0/2 (0%)
Tat	NP_666326.1	tyr_amTase_E	41..442	CDD:273529	213/405 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847247
Domainoid	1	1.000	410	1.000	Domainoid score	I690
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37293
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1559
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S2031
OMA	1	1.010	-	-		QHG53692
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001879
OrthoInspector	1	1.000	-	-		oto95285
orthoMCL	1	0.900	-	-		OOG6_101502
Panther	1	1.100	-	-	LDO	PTHR45744
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4134
SonicParanoid	1	1.000	-	-		X1408
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740