Protein Alignment HOXD12 and E5

DIOPT Version :10

• Sequence 1: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 72/311 - (23%)
• Similarity: 101/311 - (32%)
• Gaps: 104/311 - (33%)

Human    20 SPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQP--------AGATAFGGFSQPY 76
            ||.:...|..|...|.:......|..|...| ..:|.|.:|:.|        ||.||..|...
  Fly    85 SPTNTNNSGRRTPRGYIYCRRRDSLDRSRSP-QRSPVSRSPSPPNAGGNPAAAGNTAKSGDPS-- 146

Human    77 LAGSG-------PLGLQPPT-AKDGPEEQAKFYAPEAAAGPEERGRTRPSFAPESSLAPAVAALK 133
             :|:|       ||.|..|. |..|........|...|..|....:..|..|.:..:|.|:|...
  Fly   147 -SGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHH 210

Human   134 AAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAGVASCLRPSLPDGL----- 193
            ..:...         ....|...|..|     ..||                .|.||.|.
  Fly   211 QQQQQQ---------QQQQLPPVPTGP-----PHGP----------------HPHLPPGQIPLGI 245

Human   194 ----------------PWGAAPGRARKK---------------------------RKP------Y 209
                            |:|:||...|..                           |||      :
  Fly   246 FPGGPHPGHPPPHGHHPFGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAF 310

Human   210 TKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRV 260
            :..|:.:||:.|..|.::...:||:|:..|:|::.|||:||||||.|.||:
  Fly   311 SPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRM 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		5/19 (26%)
		Homeodomain	203..259	CDD:459649	24/88 (27%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	20/55 (36%)