Protein Alignment HOXD12 and Hmx

DIOPT Version :10

• Sequence 1: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 45/214 - (21%)
• Similarity: 74/214 - (34%)
• Gaps: 89/214 - (41%)

Human    60 PAQPAGATAFGGFS------QPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPS 118
            |..|..:::.||.|      .|:|.||....|.|.::.:..||..:....:
  Fly   397 PTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEED-------------- 447

Human   119 FAPESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAGVAS 183
                                                         |.|.||.:
  Fly   448 ---------------------------------------------DGTDGPSD------------ 455

Human   184 CLRPSLPDGLPWGAAPGRARKKRKP---YTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQ 245
               .|.|.|      .|.:::|:|.   :::.|:.:||:.|.:..:::..:|..|:..|.|::.|
  Fly   456 ---SSSPHG------DGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQ 511

Human   246 VKIWFQNRRMKKKRVVLRE 264
            |||||||||.|.||.:..|
  Fly   512 VKIWFQNRRNKWKRQLAAE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		0/19 (0%)
		Homeodomain	203..259	CDD:459649	21/58 (36%)
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	20/55 (36%)