Protein Alignment HOXD12 and abd-A

DIOPT Version :10

• Sequence 1: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_732176.1
• Gene: abd-A / 42037
• FlyBaseID: FBgn0000014
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 271
• Identity: 69/271 - (25%)
• Similarity: 108/271 - (39%)
• Gaps: 93/271 - (34%)

Human    52 AATPASCAPAQPAGATAFGGFS------QPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPE 110
            :|..:..|.|..|.|.|...|:      .||::..       |::..|....|.|      .|.|
  Fly   234 SAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNH-------PSSHGGLSGMAGF------TGLE 285

Human   111 ERGRTR--------------PSFAP---------ESSLAPAVAALKAAKYDYAGVGRA-TPGSTT 151
            ::..:|              |:.|.         .::.|.||:|..|.......:|.| |..::.
  Fly   286 DKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNACTQPASG 350

Human   152 LLQGAPCAPGFKDDTKGPLNLNMTVQAAGVASCLR-PSL--------------------PDGLPW 195
            ::.||..|.|                 ||:|...| |.:                    |:|.|
  Fly   351 VMPGAGGAGG-----------------AGIADLPRYPWMTLTDWMGSPFERVVCGDFNGPNGCP- 397

Human   196 GAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRV 260
                  .|:.|:.||:.|..|||.||..|.::.|::|.|:::.|.|:::|:||||||||||.|:.
  Fly   398 ------RRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKE 456

Human   261 V-----LREQA 266
            :     :.|||
  Fly   457 LRAVKEINEQA 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		5/42 (12%)
		Homeodomain	203..259	CDD:459649	27/55 (49%)
abd-A	NP_732176.1	Homeodomain	399..455	CDD:459649	27/55 (49%)
		Abdominal-A	456..478	CDD:403567	3/12 (25%)