Protein Alignment HOXD12 and ems

DIOPT Version :10

• Sequence 1: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 258
• Identity: 66/258 - (25%)
• Similarity: 92/258 - (35%)
• Gaps: 86/258 - (33%)

Human    40 PPISYPRGAL--PWAATPASCAPAQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPE-EQAKFY 101
            ||.:||:.|:  |..|.|.......|||..      :|:..|.|    .||..:..|. ...|..
  Fly   238 PPPNYPKPAMMHPGGAGPMMMPGMPPAGLV------RPFPMGPG----GPPMPQGQPGLPDIKAL 292

Human   102 APEAAAGPEERGRTRPSFAPESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDT 166
            .|...|.||...:..|..            :.||::..|...:|                  ...
  Fly   293 PPYINAPPELPPQHNPHL------------IAAAQFQMAAALQA------------------GHV 327

Human   167 KGPLNLNMTVQAAGVASCLRPSLPDGLPWGAAPGRARKK-------------------------- 205
            .||      ..||..|:.|.|.....:|   .||.||..
  Fly   328 LGP------AAAAAAAAGLPPHAAQFMP---NPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVP 383

Human   206 --RKP------YTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRV 260
              |||      ::..|:.:||:.|..|:::...:||.|:..||||:.|||:||||||.|.||:
  Fly   384 PFRKPKRIRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTKHKRM 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		5/19 (26%)
		Homeodomain	203..259	CDD:459649	26/89 (29%)
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	22/55 (40%)