Protein Alignment HOXD12 and cad

DIOPT Version :10

• Sequence 1: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 63/281 - (22%)
• Similarity: 94/281 - (33%)
• Gaps: 92/281 - (32%)

Human    64 AGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFAP------E 122
            |.|.:.|.:..|..:.:.......||:.....:|...:...|::.....|.:....||      |
  Fly    75 AAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNE 139

Human   123 SSLAPAVAALKAAKYDYAGVGRAT---PGSTT------LLQGAP-----------CAPGFKDDTK 167
            ::.:..|......    .|||.||   |||..      :.:|.|           .:||......
  Fly   140 TNSSIGVGGAGGG----GGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSAS 200

Human   168 GP------------------------------LNLNMTVQAAGVASCLRPSLPDGLPWGAAP--- 199
            .|                              .|.|.:|......|   ||.|....|...|
  Fly   201 SPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTS---PSKPPYFDWMKKPAYP 262

Human   200 -----------------------GRARKK---RKPYTKQQIAELENEFLVNEFINRQKRKELSNR 238
                                   |:.|.|   |..||..|..|||.|:..:.:|..:::.||:..
  Fly   263 AQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQT 327

Human   239 LNLSDQQVKIWFQNRRMKKKR 259
            |:||::||||||||||.|:::
  Fly   328 LSLSERQVKIWFQNRRAKERK 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		4/25 (16%)
		Homeodomain	203..259	CDD:459649	27/58 (47%)
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	25/54 (46%)