DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRNA-cap and DUSP11

DIOPT Version :9

Sequence 1:	NP_572952.1	Gene:	mRNA-cap / 32379	FlyBaseID:	FBgn0030556	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_003575.3	Gene:	DUSP11 / 8446	HGNCID:	3066	Length:	330	Species:	Homo sapiens

Alignment Length:	366	Identity:	93/366 - (25%)
Similarity:	142/366 - (38%)	Gaps:	106/366 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RERGSGPLPNRWL-YCP---RKSDTIIAERFLAFKTPLSNNFHDKM-PIECTFQPEMLFEYCKTL 67
            :::|...:|.||. |.|   |...|    ||:|||.||..:|..|: |.|| |.|..||...:..
Human    24 KKKGGNHIPERWKDYLPVGQRMPGT----RFIAFKVPLQKSFEKKLAPEEC-FSPLDLFNKIREQ 83

  Fly    68 KVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERPFD-- 130
            ..:|||.:|||.|:|:|....:.|. ..|:|:...|| :.|..|....|...|:.|:.|...:
Human    84 NEELGLIIDLTYTQRYYKPEDLPET-VPYLKIFTVGH-QVPDDETIFKFKHAVNGFLKENKDNDK 146

  Fly   131 VIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYEDTNAAPA 195
            :|.||||||.||||:||..||::........|:.:|...|...:.:|:||.:|..
Human   147 LIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQN---------- 201

  Fly   196 APEQPNWCLDYDDGNGDGFVQDNSSSTSQQAGEQDDDA-------------------EEVEGEDA 241
            .|.:.||                 :|:..::.:.:|.|                   .:::|..|
Human   202 GPIRKNW-----------------NSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYNLHQIQGHSA 249

  Fly   242 GGDCDASTSDGQPRKKRRREMIIKNATFMAGVPGVRQVSDQPRL-------------GDLQRKVQ 293
                        ||....:...::.:        ||:.|:.|.:             .|...:..
Human   250 ------------PRHFHTQTQSLQQS--------VRKFSENPHVYQRHHLPPPGPPGEDYSHRRY 294

  Fly   294 DWCDWKKNGFPGAQPVSMDRE-----NIKRLSEIPYRVSWK 329
            .|     |..|.|...:.||.     |..|||   |...|:
Human   295 SW-----NVKPNASRAAQDRRRWYPYNYSRLS---YPACWE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRNA-cap	NP_572952.1	PTPc	<116..171	CDD:304379	21/56 (38%)
		mRNA_cap_enzyme	307..497	CDD:279649	8/28 (29%)
		mRNA_cap_C	502..597	CDD:281856
DUSP11	NP_003575.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1544021at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820