DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mRNA-cap and rngtt

DIOPT Version :9

Sequence 1:	NP_572952.1	Gene:	mRNA-cap / 32379	FlyBaseID:	FBgn0030556	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_998032.1	Gene:	rngtt / 405803	ZFINID:	ZDB-GENE-040426-2087	Length:	598	Species:	Danio rerio

Alignment Length:	618	Identity:	304/618 - (49%)
Similarity:	400/618 - (64%)	Gaps:	40/618 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PNRWLYCPRKSDTIIAERFLAFKTPLSNNFHDKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNT 80
            |.||..|||:... :|.:||..||.|...:.||:|.|..|.|.||..|.|:||||:||.||||||
Zfish     7 PPRWRNCPRRGQP-VAGKFLPMKTMLGPRYDDKVPEENRFHPSMLSNYLKSLKVKMGLLVDLTNT 70

  Fly    81 KRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTGF 145
            .|||||:.:|:.|.||:||.|:||||.|:.|.|..||.:.::||.:.|.::|.||||||||||||
Zfish    71 TRFYDRADIEKEGIKYVKLSCKGHGECPTAETTEMFIRLCEHFIEKTPTELIGVHCTHGFNRTGF 135

  Fly   146 LIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYEDTNAAPAAPEQPNWCLDYDDGN 210
            ||..||||::|.|:.||:|.||.||||||||.||:.||::||.|...|||||..|.||.|.|:
Zfish   136 LICAYLVEKMDWSIEAAVAAFAQARPPGIYKGDYLKELFRRYGDVEDAPAAPPLPEWCFDEDE-- 198

  Fly   211 GDGFVQDNSSSTSQQAGEQDDDAEEVEGEDAGGDCDASTSDGQPRKKRRREMIIKNATFMAG--V 273
                         ::.||:|..|.....|      .:|:..||.:||:.|..:  .|.|:.|  |
Zfish   199 -------------EEDGEEDGSASAPASE------PSSSHTGQSKKKKERLKL--GAVFLEGVSV 242

  Fly   274 PGVRQVSDQPRLGDLQRKVQDWCDWKKNGFPGAQPVSMDRENIKRLSEIPYRVSWKADGTRYMML 338
            .||.||:.||:||::|||.|.:.:|.::||||||||||||:||:.|.:..|:|||||||||||||
Zfish   243 KGVSQVTTQPKLGEIQRKCQQFSEWDRSGFPGAQPVSMDRKNIRMLEQNGYKVSWKADGTRYMML 307

  Fly   339 IDGRDEVYFFDRNHSCFQVENVTFVESRNLNEHLDGTLVDGEMVLDKIGETVTPRYLIYDIVRLS 403
            ||||:|||..||::|.|.:||:.|...::|..||..||:||||::||:.....||||||||::.|
Zfish   308 IDGRNEVYMIDRDNSVFHIENLEFPFRKDLRIHLSNTLLDGEMIIDKVNGQPVPRYLIYDIIKFS 372

  Fly   404 NRDVRDEPFYPNRLDYIKTEVIGPRILGMKHGIINQRLQAFSVRGKDFWDIWMSARLLGEKFSRT 468
            .:.|....| ..||..|:.|:|.||...||.|.|::..:.||||.|.|:||..:.:||...|:..
Zfish   373 GQPVGQCDF-NRRLLCIEKEIISPRFEKMKLGQIDKAKEPFSVRNKPFFDIHAARKLLEGSFTSQ 436

  Fly   469 LAHEPDGLIFQPSKQPYTAGTCSDVFKWKPHELNSVDFRLKIITERGEGLLTKKVGFLYVGGHDA 533
            ::||.|||||||..: |..|.|.|:.||||...|||||||||....||||:.:.||.||||.:|.
Zfish   437 VSHEVDGLIFQPIGK-YKPGRCDDILKWKPPSHNSVDFRLKITKVGGEGLIPQTVGLLYVGNYDM 500

  Fly   534 PYGRMQRLTKETRELDNRIVECTMNQFGN--WDFMRERTDKKNPNSYNTARSVVDSIKHPVTKEY 596
            |:.:| ::||:.::.||:|:|||   |.|  |.|||:|.||..||:|:||.:|.:||:||||||.
Zfish   501 PFAQM-KITKDLKQYDNKIIECT---FVNNTWVFMRQRVDKSFPNAYDTAMAVCNSIQHPVTKEI 561

  Fly   597 LLNF------IASSGYRNDHVMMPPPINSHNQN 623
            ||.|      :.|.....|..:||||....:.|
Zfish   562 LLEFLERCAQVQSRKNPADSDLMPPPPPKRSAN 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRNA-cap	NP_572952.1	PTPc	<116..171	CDD:304379	32/54 (59%)
		mRNA_cap_enzyme	307..497	CDD:279649	96/189 (51%)
		mRNA_cap_C	502..597	CDD:281856	53/96 (55%)
rngtt	NP_998032.1	TPase	1..215		114/229 (50%)
		PTPc	37..>143	CDD:304379	63/105 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..227		16/61 (26%)
		GTase	233..598		184/368 (50%)
		Adenylation_mRNA_capping	252..465	CDD:185706	110/214 (51%)
		mRNA_cap_C	469..562	CDD:281856	53/96 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..598		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574400
Domainoid	1	1.000	190	1.000	Domainoid score	I3216
eggNOG	1	0.900	-	-		E1_COG5226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37851
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1014
OMA	1	1.010	-	-		QHG57294
OrthoDB	1	1.010	-	-		D1544021at2759
OrthoFinder	1	1.000	-	-		FOG0003817
OrthoInspector	1	1.000	-	-		oto38862
orthoMCL	1	0.900	-	-		OOG6_101990
Panther	1	1.100	-	-	LDO	PTHR10367
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R688
SonicParanoid	1	1.000	-	-		X2661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800