DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mRNA-cap and Rngtt

DIOPT Version :9

Sequence 1:	NP_572952.1	Gene:	mRNA-cap / 32379	FlyBaseID:	FBgn0030556	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001101393.1	Gene:	Rngtt / 313131	RGDID:	1311410	Length:	597	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	297/616 - (48%)
Similarity:	399/616 - (64%)	Gaps:	47/616 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPNRWLYCPRKSDTIIAERFLAFKTPLSNNFHDKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTN 79
            :|.|||.|||:... :|.|||..||.|...:..::..|..|.|.||..|.|:||||:.|.|||||
  Rat     6 IPPRWLNCPRRGQP-VAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMSLLVDLTN 69

  Fly    80 TKRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTG 144
            |.|||||:.:|:.|.|||||||:||||.|:.|.|.:||.:.:.|....|.::|.|||||||||||
  Rat    70 TSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERSPPELIGVHCTHGFNRTG 134

  Fly   145 FLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYEDTNAAPAAPEQPNWCLDYDDG 209
            |||..:|||::|.|:.||:|.||.||||||||.||:.||::||.|...||..|..|:||.:.||
  Rat   135 FLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPVLPDWCFEDDD- 198

  Fly   210 NGDGFVQDNSSSTSQQAGEQDDDAEEVEGEDAGGDCDASTSDGQPRKKRRREMIIKNATFMAG-- 272
                              |:|:|.:..:..:.|    :|.|.|    |||:|.:...|.|:.|
  Rat   199 ------------------EEDEDEDGKKDSEPG----SSASFG----KRRKERLKLGAIFLEGIT 237

  Fly   273 VPGVRQVSDQPRLGDLQRKVQDWCDWKKNGFPGAQPVSMDRENIKRLSEIPYRVSWKADGTRYMM 337
            |.||.||:.||:||::|:|...:|.|:.:|||||||||||::||:.|.:.||:||||||||||||
  Rat   238 VKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIRLLEQKPYKVSWKADGTRYMM 302

  Fly   338 LIDGRDEVYFFDRNHSCFQVENVTFVESRNLNEHLDGTLVDGEMVLDKIGETVTPRYLIYDIVRL 402
            ||||.:||:..||::|.|.|.|:.|...::|..||..||:||||::||:.....||||||||::.
  Rat   303 LIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDKVNGQAVPRYLIYDIIKF 367

  Fly   403 SNRDVRDEPFYPN-RLDYIKTEVIGPRILGMKHGIINQRLQAFSVRGKDFWDIWMSARLLGEKFS 466
            :.:.|.:..|  | ||..|:.|:|.||...||.|:|::..:.||||.|.|:||.:|.:||...|:
  Rat   368 NAQPVGECDF--NIRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRPKQFFDINISRKLLEGNFA 430

  Fly   467 RTLAHEPDGLIFQPSKQPYTAGTCSDVFKWKPHELNSVDFRLKIITERGEGLLTKKVGFLYVGGH 531
            :.::||.|||||||..: |..|.|.|:.||||..||||||||||....|||||.:.||.|||||:
  Rat   431 KEVSHEMDGLIFQPIGK-YKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGY 494

  Fly   532 DAPYGRMQRLTKETRELDNRIVECTMNQFGNWDFMRERTDKKNPNSYNTARSVVDSIKHPVTKEY 596
            :.|:.:: ::|||.::.||:|:||.... .:|.|||:|.||..||:||||.:|.:||.:|||||.
  Rat   495 ERPFAQI-KVTKELKQYDNKIIECKFEN-NSWVFMRQRIDKSFPNAYNTAMAVCNSISNPVTKEM 557

  Fly   597 LLNFI-----ASSGYRN------DHVMMPPP 616
            |..||     |:.|.:.      |..:||||
  Rat   558 LFEFIDRCAAAAQGQKRKYPMDPDSELMPPP 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRNA-cap	NP_572952.1	PTPc	<116..171	CDD:304379	30/54 (56%)
		mRNA_cap_enzyme	307..497	CDD:279649	95/190 (50%)
		mRNA_cap_C	502..597	CDD:281856	51/94 (54%)
Rngtt	NP_001101393.1	Mce1_N	9..175	CDD:350502	93/166 (56%)
		Adenylation_mRNA_capping	248..461	CDD:185706	108/215 (50%)
		mRNA_cap_C	465..558	CDD:397827	51/94 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335143
Domainoid	1	1.000	190	1.000	Domainoid score	I3192
eggNOG	1	0.900	-	-		E1_COG5226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37851
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1057
OMA	1	1.010	-	-		QHG57294
OrthoDB	1	1.010	-	-		D1544021at2759
OrthoFinder	1	1.000	-	-		FOG0003817
OrthoInspector	1	1.000	-	-		oto98215
orthoMCL	1	0.900	-	-		OOG6_101990
Panther	1	1.100	-	-	LDO	PTHR10367
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2661
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770