DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and GRR1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_012623.1	Gene:	GRR1 / 853552	SGDID:	S000003850	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	122/535 - (22%)
Similarity:	202/535 - (37%)	Gaps:	143/535 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQ-------ITQHSRTL----------- 257
            |.||||.:...::|..::..:.|   ...:|:|:..:..       |.::.::|
Yeast   192 KELRIDNSPQAISYLHKLQRMRL---RALETENMEIRNLRLKILTIIEEYKKSLYAYCHSKLRGQ 253

  Fly   258 -VSPPPD-------AIGST-SGDGSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQFLADN 313
             |..|.|       :|.:| |.|...|.               :|.:....:||||.||.....|
Yeast   254 QVENPTDNFIIWINSIDTTESSDLKEGL---------------QDLSRYSRQFINNVLSNPSNQN 303

  Fly   314 -CVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRH---PLLYAEISLK-- 372
             |......:|...|..||.|||..||..|:.|            |||.:.   ..|:|||.:|
Yeast   304 ICTSVTRRSPVFALNMLPSEILHLILDKLNQK------------YDIVKFLTVSKLWAEIIVKIL 356

  Fly   373 ---PYWDVASSELLCTLARRAT----------MLRKLDLSWCGGFGNVSPTEFKKFLTQRG-DNL 423
               |:.:..|...|.....:.|          |:::|:.|:.|.:  :..||...|:..:. :.|
Yeast   357 YYRPHINKKSQLDLFLRTMKLTSEETVFNYRLMIKRLNFSFVGDY--MHDTELNYFVGCKNLERL 419

  Fly   424 T-----HLR-------LNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLE 476
            |     |:.       |..||||.:..|..:..|.|::.:    ..||..|.:....:...:|:
Yeast   420 TLVFCKHITSVPISAVLRGCKFLQSVDITGIRDVSDDVFD----TLATYCPRVQGFYVPQARNV- 479

  Fly   477 RLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVNM-DNVAAHLATYNTQLISLDL-WKAHFL 539
                  |:   :.|.:.:..:..||.:.:.   .:.|| |.:...||.....|:.:|: ...:..
Yeast   480 ------TF---DSLRNFIVHSPMLKRIKIT---ANNNMNDELVELLANKCPLLVEVDITLSPNVT 532

  Fly   540 SSRGLQSLARLHQLEELDLGWCMREASLGDGLFQLLSN--------------------------- 577
            .|..|:.|.||.||.|..:   ....::.|.|||.||.
Yeast   533 DSSLLKLLTRLVQLREFRI---THNTNITDNLFQELSKVVDDMPSLRLIDLSGCENITDKTIESI 594

  Fly   578 ---CPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLS 639
               .|||:.:||......|:..|..::.|||||:.:......|||...|..:..:|.::|.:|.:
Yeast   595 VNLAPKLRNVFLGKCSRITDASLFQLSKLGKNLQTVHFGHCFNITDNGVRALFHSCTRIQYVDFA 659

  Fly   640 FCDNIMDRDFDLLAE 654
            .|.|:.:|....||:
Yeast   660 CCTNLTNRTLYELAD 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	17/48 (35%)
		leucine-rich repeat	393..422	CDD:275381	6/29 (21%)
		leucine-rich repeat	423..442	CDD:275381	9/30 (30%)
		LRR_RI	437..>641	CDD:238064	51/235 (22%)
		leucine-rich repeat	449..474	CDD:275381	3/24 (13%)
		leucine-rich repeat	475..499	CDD:275381	2/23 (9%)
		leucine-rich repeat	500..527	CDD:275381	7/27 (26%)
		leucine-rich repeat	528..552	CDD:275381	7/24 (29%)
		AMN1	552..>660	CDD:187754	33/133 (25%)
		leucine-rich repeat	553..580	CDD:275381	8/56 (14%)
		leucine-rich repeat	581..606	CDD:275381	7/24 (29%)
		leucine-rich repeat	607..632	CDD:275381	6/24 (25%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
GRR1	NP_012623.1	F-box-like	320..361	CDD:403981	17/52 (33%)
		AMN1	404..559	CDD:187754	37/174 (21%)
		leucine-rich repeat	416..441	CDD:275381	5/24 (21%)
		leucine-rich repeat	442..467	CDD:275381	6/28 (21%)
		leucine-rich repeat	494..519	CDD:275381	7/27 (26%)
		leucine-rich repeat	520..545	CDD:275381	7/24 (29%)
		leucine-rich repeat	546..574	CDD:275381	8/30 (27%)
		AMN1	<574..737	CDD:187754	24/101 (24%)
		leucine-rich repeat	575..600	CDD:275381	0/24 (0%)
		leucine-rich repeat	601..626	CDD:275381	7/24 (29%)
		leucine-rich repeat	627..652	CDD:275381	6/24 (25%)
		leucine-rich repeat	653..677	CDD:275381	7/22 (32%)
		leucine-rich repeat	678..704	CDD:275381
		leucine-rich repeat	707..732	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810