DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and RAD7

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_012586.1 Gene:RAD7 / 853512 SGDID:S000003813 Length:565 Species:Saccharomyces cerevisiae


Alignment Length:509 Identity:112/509 - (22%)
Similarity:186/509 - (36%) Gaps:138/509 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 PPPLDSRRFAPSLKK----TTMLTKTLR------IDFNHSRLNYYTEIDAIMLCGRTVTKTQNLL 245
            |..|.|.....||.|    |..:.:..|      .|....|:|..:.:.:  ||   :||....:
Yeast   121 PVSLSSANDRESLTKKRQNTAKIIQNRRRKRKRAADLLDRRVNKVSSLQS--LC---ITKISENI 180

  Fly   246 AKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQFL 310
            :|.|                  ...|.|...:.:|||.:     .|......|     |:|::.|
Yeast   181 SKWQ------------------KEADESSKLVFNKLRDV-----LGGVSTANL-----NNLAKAL 217

  Fly   311 ADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYW 375
            :.|          ..|.|...::.|:    .|||.|        ||.|.|:       ||...| 
Yeast   218 SKN----------RALNDHTLQLFLK----TDLKRL--------TFSDCSK-------ISFDGY- 252

  Fly   376 DVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIE 440
                    .|||..:..|.:|.|..||...:    |...::.::..||..|.|:....:|....|
Yeast   253 --------KTLAIFSPHLTELSLQMCGQLNH----ESLLYIAEKLPNLKSLNLDGPFLINEDTWE 305

  Fly   441 NVGIVCDNLIE---LSLRNCATEPPLLNF-----SCLANLKNLERLDLFQTY------------- 484
            ...::....:|   :|..:..|:..|.|.     |.|.:| .|.|||....|             
Yeast   306 KFFVIMKGRLEEFHISNTHRFTDKSLSNLLINCGSTLVSL-GLSRLDSISNYALLPQYLVNDEFH 369

  Fly   485 ------------FETELLLSML-EGNRKLKHLNLAFCGVSVNMDNVAAHLATY---NTQLISLDL 533
                        ...|:::::| :..|.|:.|.|..| :.:....:...|..:   ...|..|.|
Yeast   370 SLCIEYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGC-IDLTDSMIINGLTAFIPEKCPLEVLSL 433

  Fly   534 WKAHFLSSRGLQ---SLARLHQLEELDLGWCMREASLGD-GLFQLLSNCPK--LKKLFLSAVRGT 592
            .::..:::..|.   |...|:.|.|.....|::   ||| .:.:||.|..:  |:.|.|::::..
Yeast   434 EESDQITTDSLSYFFSKVELNNLIECSFRRCLQ---LGDMAIIELLLNGARDSLRSLNLNSLKEL 495

  Fly   593 TERDLMHIAALGKNLEQLDLMGILNITHERVYDIL-VNCPKLQLLDLSFCDNIM 645
            |:...:.:|.  .||..||| |.:....:.|..:| ...|.|.::|: |.||::
Yeast   496 TKEAFVALAC--PNLTYLDL-GFVRCVDDSVIQMLGEQNPNLTVIDV-FGDNLV 545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 13/45 (29%)
leucine-rich repeat 393..422 CDD:275381 6/28 (21%)
leucine-rich repeat 423..442 CDD:275381 5/18 (28%)
LRR_RI 437..>641 CDD:238064 53/247 (21%)
leucine-rich repeat 449..474 CDD:275381 8/32 (25%)
leucine-rich repeat 475..499 CDD:275381 7/49 (14%)
leucine-rich repeat 500..527 CDD:275381 5/29 (17%)
leucine-rich repeat 528..552 CDD:275381 6/26 (23%)
AMN1 552..>660 CDD:187754 28/98 (29%)
leucine-rich repeat 553..580 CDD:275381 9/27 (33%)
leucine-rich repeat 581..606 CDD:275381 5/24 (21%)
leucine-rich repeat 607..632 CDD:275381 7/25 (28%)
leucine-rich repeat 633..652 CDD:275381 5/13 (38%)
RAD7NP_012586.1 AMN1 228..440 CDD:187754 51/245 (21%)
leucine-rich repeat 236..261 CDD:275381 13/48 (27%)
leucine-rich repeat 262..287 CDD:275381 6/28 (21%)
leucine-rich repeat 288..340 CDD:275381 10/51 (20%)
leucine-rich repeat 342..365 CDD:275381 7/23 (30%)
leucine-rich repeat 368..397 CDD:275381 2/28 (7%)
leucine-rich repeat 398..426 CDD:275381 5/28 (18%)
leucine-rich repeat 428..455 CDD:275381 6/26 (23%)
leucine-rich repeat 456..475 CDD:275381 6/21 (29%)
leucine-rich repeat 484..507 CDD:275381 5/24 (21%)
leucine-rich repeat 508..533 CDD:275381 7/25 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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