DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and KDM2B

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011537169.1	Gene:	KDM2B / 84678	HGNCID:	13610	Length:	1353	Species:	Homo sapiens

Alignment Length:	490	Identity:	97/490 - (19%)
Similarity:	163/490 - (33%)	Gaps:	163/490 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 EATESDLSRPPPLDSR--RFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNL 244
            |:...:..|||.:..|  ||:..|..|   .:.||.....|          :....|.:::....
Human   981 ESEGEEPKRPPGICERPHRFSKGLNGT---PRELRHQLGPS----------LRSPPRVISRPPPS 1032

  Fly   245 LAKQQITQHSRTL-----VSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGEDGATK-LHEFIN 303
            ::..:..|..|.:     :|||||::..                        :|||.. :|.
Human  1033 VSPPKCIQMERHVIRPPPISPPPDSLPL------------------------DDGAAHVMHR--- 1070

  Fly   304 NDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAE 368
                                        |:.:.:.|||..:.|.....|.||:........|:..
Human  1071 ----------------------------EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTR 1107

  Fly   369 ISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKF 433
            |.|. :....:..:|..:.||..:  .|||||.    |:|..:. .:|..|...|..|.|:.|.:
Human  1108 IDLN-HCKSITPLMLSGIIRRQPV--SLDLSWT----NISKKQL-SWLINRLPGLRDLVLSGCSW 1164

  Fly   434 LNASCIENVGIVCDNLIELSLRNCATEPPL---LNFSCLANLKNLERLDLFQTYFETELLLSMLE 495
            :..|.:                 |::..||   |:...:..||:.:..|          |||...
Human  1165 IAVSAL-----------------CSSSCPLLRTLDVQWVEGLKDAQMRD----------LLSPPT 1202

  Fly   496 GNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHF-LSSRGLQSLARLHQLEELDLG 559
            .||            ...|||.:........:|..||:..|.. |..|.:..|::||      |.
Human  1203 DNR------------PGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLH------LS 1249

  Fly   560 WC--MREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHER 622
            :|  :.:.|:.                .|:|| |||.||         :|.:::|.....:| ::
Human  1250 YCNHVTDQSIN----------------LLTAV-GTTTRD---------SLTEINLSDCNKVT-DQ 1287

  Fly   623 VYDILVNCPKLQLLDLSFCDNIMDRDFD-LLAEWS 656
            .......|..:..:||.:|..:.....: .:||.|
Human  1288 CLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS 1322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	10/45 (22%)
		leucine-rich repeat	393..422	CDD:275381	9/28 (32%)
		leucine-rich repeat	423..442	CDD:275381	5/18 (28%)
		LRR_RI	437..>641	CDD:238064	42/209 (20%)
		leucine-rich repeat	449..474	CDD:275381	5/27 (19%)
		leucine-rich repeat	475..499	CDD:275381	5/23 (22%)
		leucine-rich repeat	500..527	CDD:275381	3/26 (12%)
		leucine-rich repeat	528..552	CDD:275381	8/24 (33%)
		AMN1	552..>660	CDD:187754	21/108 (19%)
		leucine-rich repeat	553..580	CDD:275381	3/28 (11%)
		leucine-rich repeat	581..606	CDD:275381	8/24 (33%)
		leucine-rich repeat	607..632	CDD:275381	4/24 (17%)
		leucine-rich repeat	633..652	CDD:275381	3/19 (16%)
KDM2B	XP_011537169.1	JmjC	182..257	CDD:214721
		cupin_like	229..335	CDD:304367
		zf-CXXC	<615..651	CDD:251032
		PHD_KDM2B	661..722	CDD:277114
		F-box-like	1071..1111	CDD:289689	10/39 (26%)
		leucine-rich repeat	1105..1129	CDD:275381	5/24 (21%)
		AMN1	1121..1310	CDD:187754	59/267 (22%)
		leucine-rich repeat	1130..1153	CDD:275381	9/29 (31%)
		leucine-rich repeat	1154..1177	CDD:275381	6/39 (15%)
		leucine-rich repeat	1178..1217	CDD:275381	12/60 (20%)
		leucine-rich repeat	1218..1242	CDD:275381	6/23 (26%)
		leucine-rich repeat	1243..1272	CDD:275381	14/60 (23%)
		leucine-rich repeat	1273..1297	CDD:275381	4/24 (17%)
		leucine-rich repeat	1298..1323	CDD:275381	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900