DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and VFB1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_175151.1	Gene:	VFB1 / 841121	AraportID:	AT1G47056	Length:	518	Species:	Arabidopsis thaliana

Alignment Length:	472	Identity:	125/472 - (26%)
Similarity:	188/472 - (39%)	Gaps:	122/472 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 STSGDGSGGSISHKLR----TLKFQPNCGEDGATKLHEFINNDLSQFLADNCVDGEAAAPQICLT 327
            |||  .:|.||.::.|    ||||.           .|.|.:::||             |.. .:
plant     4 STS--AAGNSILNRRRSKSFTLKFP-----------IESIESEISQ-------------PDY-TS 41

  Fly   328 DLPFEILLRILSYLDLKSLFRVGHVSRTF--------YDISRH---------PLLYA------EI 369
            .||.|.|..:..:|:..:..|...|.|.:        |.:|.|         |.|::      ::
plant    42 SLPDECLALVFQFLNSGNRKRCALVCRRWMIVEGQNRYRLSLHARSDLITSIPSLFSRFDSVTKL 106

  Fly   370 SLKPYWDVAS----SELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNS 430
            |||  .|..|    .|.|..::.|...|::|.|..|....:|....|       .:|...|::.|
plant   107 SLK--CDRRSVSIGDEALVKISLRCRNLKRLKLRACRELTDVGMAAF-------AENCKDLKIFS 162

  Fly   431 CKFLNASC------IENVGIVCDNLIELSLRN------------------------CATEPPLLN 465
            |    .||      ::.|...|.||.|||::.                        |..|  |.|
plant   163 C----GSCDFGAKGVKAVLDHCSNLEELSIKRLRGFTDIAPEMIGPGVAASSLKSICLKE--LYN 221

  Fly   466 FSC----LANLKNLERLDLFQTYFETELLLSMLEG-NRKLKHLNLAFCGVSVNMDNVAAHLATYN 525
            ..|    :...|||:.|.||:...:.:|||..:.| :..:..::|....||    :||....:|.
plant   222 GQCFGPVIVGAKNLKSLKLFRCSGDWDLLLQEMSGKDHGVVEIHLERMQVS----DVALSAISYC 282

  Fly   526 TQLISLDLWKAHFLSSRGLQSLA-RLHQLEELDL-GWCMREASL-GD-GLFQLLSNCPKLKKLFL 586
            :.|.||.|.|....::.||.::| :..:|.:|.: ||   :|:| || ||..:...|.:|::|.|
plant   283 SSLESLHLVKTPECTNFGLAAIAEKCKRLRKLHIDGW---KANLIGDEGLVAVAKFCSQLQELVL 344

  Fly   587 SAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDL 651
            ..|..|| ..|..:||...|||:|.|.|........:..|...||.|:.|.:..|. |.|...:.
plant   345 IGVNPTT-LSLGMLAAKCLNLERLALCGCDTFGDPELSCIAAKCPALRKLCIKNCP-ISDVGIEN 407

  Fly   652 LAEWSRQF-KVDIKSSR 667
            ||...... ||.||..:
plant   408 LANGCPGLTKVKIKKCK 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	14/68 (21%)
		leucine-rich repeat	393..422	CDD:275381	6/28 (21%)
		leucine-rich repeat	423..442	CDD:275381	5/24 (21%)
		LRR_RI	437..>641	CDD:238064	69/242 (29%)
		leucine-rich repeat	449..474	CDD:275381	9/52 (17%)
		leucine-rich repeat	475..499	CDD:275381	8/24 (33%)
		leucine-rich repeat	500..527	CDD:275381	6/26 (23%)
		leucine-rich repeat	528..552	CDD:275381	8/24 (33%)
		AMN1	552..>660	CDD:187754	36/111 (32%)
		leucine-rich repeat	553..580	CDD:275381	11/29 (38%)
		leucine-rich repeat	581..606	CDD:275381	9/24 (38%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
VFB1	NP_175151.1	F-box-like	41..>70	CDD:403981	8/28 (29%)
		AMN1	87..>202	CDD:187754	29/127 (23%)
		leucine-rich repeat	103..125	CDD:275381	7/23 (30%)
		leucine-rich repeat	132..157	CDD:275381	7/31 (23%)
		leucine-rich repeat	158..182	CDD:275381	7/27 (26%)
		leucine-rich repeat	183..224	CDD:275381	8/42 (19%)
		leucine-rich repeat	235..260	CDD:275381	8/24 (33%)
		leucine-rich repeat	261..284	CDD:275381	6/26 (23%)
		AMN1	271..>412	CDD:187754	49/149 (33%)
		leucine-rich repeat	285..310	CDD:275381	8/24 (33%)
		leucine-rich repeat	311..338	CDD:275381	11/29 (38%)
		leucine-rich repeat	339..363	CDD:275381	9/24 (38%)
		leucine-rich repeat	364..389	CDD:275381	7/24 (29%)
		leucine-rich repeat	390..414	CDD:275381	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4364
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810