DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and SKP2A

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001321134.1	Gene:	SKP2A / 838740	AraportID:	AT1G21410	Length:	360	Species:	Arabidopsis thaliana

Alignment Length:	338	Identity:	83/338 - (24%)
Similarity:	130/338 - (38%)	Gaps:	107/338 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 DLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARRATM 392
            |:|.|:|:||||.:|.:::.                             |||.  :||..|.|..
plant    30 DIPVELLMRILSLVDDRNVI-----------------------------VASG--VCTGWRDAIS 63

  Fly   393 --LRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLR 455
              |.:|.||||                  .:|:..|.|:               :....::|...
plant    64 FGLTRLRLSWC------------------NNNMNSLVLS---------------LVPKFVKLQTL 95

  Fly   456 NCATEPPLLNFSCLANLKN----LERLDLFQTYFETE-LLLSMLEGNRKLKHLNLAFCGVSVNMD 515
            |...:.|.|..:.:..:.|    |:.|||.::...|: .|.::..|...|..|||:.|  :...|
plant    96 NLRQDKPQLEDNAVEAIANHCHELQELDLSKSLKITDRSLYALAHGCPDLTKLNLSGC--TSFSD 158

  Fly   516 NVAAHLATYNTQLISLDLW---KAHFLSSRGLQSLA-RLHQLEELDLGWCMREASLGDGLFQLLS 576
            ...|:|..:..:|..|:|.   ||  ::...|:::. ..:|::.|:||||  |....||:..|..
plant   159 TAIAYLTRFCRKLKVLNLCGCVKA--VTDNALEAIGNNCNQMQSLNLGWC--ENISDDGVMSLAY 219

  Fly   577 NCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFC 641
            .||                          :|..|||.|.:.||.|.|..:...|..|:.|.|.:|
plant   220 GCP--------------------------DLRTLDLCGCVLITDESVVALADWCVHLRSLGLYYC 258

  Fly   642 DNIMDRDFDLLAE 654
            .||.||....||:
plant   259 RNITDRAMYSLAQ 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	9/43 (21%)
		leucine-rich repeat	393..422	CDD:275381	6/28 (21%)
		leucine-rich repeat	423..442	CDD:275381	2/18 (11%)
		LRR_RI	437..>641	CDD:238064	51/212 (24%)
		leucine-rich repeat	449..474	CDD:275381	4/24 (17%)
		leucine-rich repeat	475..499	CDD:275381	7/24 (29%)
		leucine-rich repeat	500..527	CDD:275381	8/26 (31%)
		leucine-rich repeat	528..552	CDD:275381	6/27 (22%)
		AMN1	552..>660	CDD:187754	32/103 (31%)
		leucine-rich repeat	553..580	CDD:275381	10/26 (38%)
		leucine-rich repeat	581..606	CDD:275381	0/24 (0%)
		leucine-rich repeat	607..632	CDD:275381	10/24 (42%)
		leucine-rich repeat	633..652	CDD:275381	8/18 (44%)
SKP2A	NP_001321134.1	F-box-like	28..>63	CDD:403981	16/63 (25%)
		leucine-rich repeat	66..91	CDD:275381	9/57 (16%)
		leucine-rich repeat	92..118	CDD:275381	5/25 (20%)
		AMN1	<115..264	CDD:187754	49/180 (27%)
		leucine-rich repeat	119..144	CDD:275381	7/24 (29%)
		leucine-rich repeat	145..170	CDD:275381	8/26 (31%)
		leucine-rich repeat	171..197	CDD:275381	6/27 (22%)
		leucine-rich repeat	198..223	CDD:275381	11/52 (21%)
		leucine-rich repeat	224..249	CDD:275381	10/24 (42%)
		leucine-rich repeat	250..272	CDD:275381	10/22 (45%)
		leucine-rich repeat	294..313	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810