DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and EBF2

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_197917.1	Gene:	EBF2 / 832607	AraportID:	AT5G25350	Length:	623	Species:	Arabidopsis thaliana

Alignment Length:	344	Identity:	88/344 - (25%)
Similarity:	139/344 - (40%)	Gaps:	90/344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 WDV-ASSEL-LCTLARRATMLRKLDLSWCGGF---GNVSPTEFKKFLTQRGDNLTHLRLNSCKFL 434
            |:: |.|:| |..:||...|:.|||||.|.|.   |.|:       :.:...||:.|.::||..:
plant   175 WNLPAVSDLGLSEIARSCPMIEKLDLSRCPGITDSGLVA-------IAENCVNLSDLTIDSCSGV 232

  Fly   435 NASCIENVGIVCDNLIELSLRNC--------------------ATEPPLLNFSCLANLKNLERLD 479
            ....:..:...|.||..:|:|:|                    ..:..:||.|.|:       |.
plant   233 GNEGLRAIARRCVNLRSISIRSCPRIGDQGVAFLLAQAGSYLTKVKLQMLNVSGLS-------LA 290

  Fly   480 LFQTY--FETELLLSMLE--------------GNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQL 528
            :...|  ..|:|:|..|:              |.:|||.|::..|....::...|......:.:.
plant   291 VIGHYGAAVTDLVLHGLQGVNEKGFWVMGNAKGLKKLKSLSVMSCRGMTDVGLEAVGNGCPDLKH 355

  Fly   529 ISLDLWKAHFLSSRGLQSLAR-LHQLEELDLGWCMREASLGDGLFQLLSNC-PKLKKLFLSAVRG 591
            :||:  |...:|.:||.:||: ...||.|.|..|.|....  ||...|.|| .|||...|:...|
plant   356 VSLN--KCLLVSGKGLVALAKSALSLESLKLEECHRINQF--GLMGFLMNCGSKLKAFSLANCLG 416

  Fly   592 TTE---------------RDL----------MHIAALGK---NLEQLDLMGILNITHERVYDIL- 627
            .::               |.|          ..:|.|||   .|:.::|.|:..:|...|.::|
plant   417 ISDFNSESSLPSPSCSSLRSLSIRCCPGFGDASLAFLGKFCHQLQDVELCGLNGVTDAGVRELLQ 481

  Fly   628 VNCPKLQLLDLSFCDNIMD 646
            .|...|..::||.|.|:.|
plant   482 SNNVGLVKVNLSECINVSD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689
		leucine-rich repeat	393..422	CDD:275381	9/31 (29%)
		leucine-rich repeat	423..442	CDD:275381	4/18 (22%)
		LRR_RI	437..>641	CDD:238064	63/270 (23%)
		leucine-rich repeat	449..474	CDD:275381	8/44 (18%)
		leucine-rich repeat	475..499	CDD:275381	7/39 (18%)
		leucine-rich repeat	500..527	CDD:275381	5/26 (19%)
		leucine-rich repeat	528..552	CDD:275381	8/24 (33%)
		AMN1	552..>660	CDD:187754	35/125 (28%)
		leucine-rich repeat	553..580	CDD:275381	11/27 (41%)
		leucine-rich repeat	581..606	CDD:275381	10/52 (19%)
		leucine-rich repeat	607..632	CDD:275381	7/25 (28%)
		leucine-rich repeat	633..652	CDD:275381	6/14 (43%)
EBF2	NP_197917.1	F-box	54..>92	CDD:279040
		AMN1	<138..268	CDD:187754	28/99 (28%)
		leucine-rich repeat	169..194	CDD:275381	7/18 (39%)
		leucine-rich repeat	195..220	CDD:275381	9/31 (29%)
		leucine-rich repeat	221..246	CDD:275381	5/24 (21%)
		leucine-rich repeat	247..278	CDD:275381	4/30 (13%)
		leucine-rich repeat	279..326	CDD:275381	11/53 (21%)
		leucine-rich repeat	327..352	CDD:275381	5/24 (21%)
		leucine-rich repeat	353..378	CDD:275381	8/26 (31%)
		leucine-rich repeat	379..402	CDD:275381	9/24 (38%)
		leucine-rich repeat	406..459	CDD:275381	10/52 (19%)
		leucine-rich repeat	407..433	CDD:275381	3/25 (12%)
		AMN1	435..>582	CDD:187754	19/66 (29%)
		leucine-rich repeat	460..511	CDD:275381	13/41 (32%)
		leucine-rich repeat	487..512	CDD:275381	6/14 (43%)
		leucine-rich repeat	514..537	CDD:275381
		leucine-rich repeat	540..566	CDD:275381
		leucine-rich repeat	567..595	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810