DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and EBF1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_565597.1	Gene:	EBF1 / 817087	AraportID:	AT2G25490	Length:	628	Species:	Arabidopsis thaliana

Alignment Length:	626	Identity:	134/626 - (21%)
Similarity:	202/626 - (32%)	Gaps:	231/626 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQI 250
            :|:..||...||..||:: .:....|.:.||        ....:.:....|.::..|...|...:
plant    36 ADVYFPPSKRSRVVAPTI-FSAFEKKPVSID--------VLPDECLFEIFRRLSGPQERSACAFV 91

  Fly   251 TQHSRTLVS-------PPPDAIGSTSGDGSGGSISHKLRTLKFQP---------NCGEDGATKLH 299
            ::...||||       ..|..| :..||...|.:|..|...|...         ..|..|..||
plant    92 SKQWLTLVSSIRQKEIDVPSKI-TEDGDDCEGCLSRSLDGKKATDVRLAAIAVGTAGRGGLGKL- 154

  Fly   300 EFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFR----VGHVSRTFYDIS 360
                          .:.|..:|.               :|.|.|:|:.|    :|.:|
plant   155 --------------SIRGSNSAK---------------VSDLGLRSIGRSCPSLGSLS------- 183

  Fly   361 RHPLLYAEISLKPYWDVA--SSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRG--- 420
                         .|:|:  :...|..:|.....|.||:|:.|            ..:|.:|
plant   184 -------------LWNVSTITDNGLLEIAEGCAQLEKLELNRC------------STITDKGLVA 223

  Fly   421 -----DNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLL----------NFSC-L 469
                 .|||.|.|.:|..:....:..:...|..|..:|::||    ||:          |.:| |
plant   224 IAKSCPNLTELTLEACSRIGDEGLLAIARSCSKLKSVSIKNC----PLVRDQGIASLLSNTTCSL 284

  Fly   470 ANLKNLERLDLFQTYFE---------TELLLSMLE--------------GNRKLKHLNLAFC-GV 510
            |.|| |:.|::......         |:|:|:.|.              |.:||..|.:..| ||
plant   285 AKLK-LQMLNVTDVSLAVVGHYGLSITDLVLAGLSHVSEKGFWVMGNGVGLQKLNSLTITACQGV 348

  Fly   511 S-VNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLH-QLEELDLGWCMREASLGDGLFQ 573
            : :.:::|..........:||    |:..||..||.|.|:.. .||.|.|..|.|....  |.|.
plant   349 TDMGLESVGKGCPNMKKAIIS----KSPLLSDNGLVSFAKASLSLESLQLEECHRVTQF--GFFG 407

  Fly   574 LLSN------------------------------------------------------CPKLKKL 584
            .|.|                                                      ||:|:.:
plant   408 SLLNCGEKLKAFSLVNCLSIRDLTTGLPASSHCSALRSLSIRNCPGFGDANLAAIGKLCPQLEDI 472

  Fly   585 FLSAVRGTTERDLMHI-------------------------AALGKNLEQLDLMGILNITHERVY 624
            .|..::|.||...:|:                         |..|..||.|::.|..|||...:.
plant   473 DLCGLKGITESGFLHLIQSSLVKINFSGCSNLTDRVISAITARNGWTLEVLNIDGCSNITDASLV 537

  Fly   625 DILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQFKVDIKS 665
            .|..||..|..||:|.| .|.|.....||. |.:.|:.|.|
plant   538 SIAANCQILSDLDISKC-AISDSGIQALAS-SDKLKLQILS 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	7/49 (14%)
		leucine-rich repeat	393..422	CDD:275381	7/36 (19%)
		leucine-rich repeat	423..442	CDD:275381	5/18 (28%)
		LRR_RI	437..>641	CDD:238064	70/319 (22%)
		leucine-rich repeat	449..474	CDD:275381	11/35 (31%)
		leucine-rich repeat	475..499	CDD:275381	7/46 (15%)
		leucine-rich repeat	500..527	CDD:275381	6/28 (21%)
		leucine-rich repeat	528..552	CDD:275381	9/24 (38%)
		AMN1	552..>660	CDD:187754	40/186 (22%)
		leucine-rich repeat	553..580	CDD:275381	11/80 (14%)
		leucine-rich repeat	581..606	CDD:275381	8/49 (16%)
		leucine-rich repeat	607..632	CDD:275381	10/24 (42%)
		leucine-rich repeat	633..652	CDD:275381	7/18 (39%)
EBF1	NP_565597.1	F-box-like	64..101	CDD:372399	8/44 (18%)
		AMN1	<149..298	CDD:187754	44/215 (20%)
		leucine-rich repeat	179..204	CDD:275381	6/44 (14%)
		leucine-rich repeat	205..230	CDD:275381	7/36 (19%)
		leucine-rich repeat	231..256	CDD:275381	6/24 (25%)
		leucine-rich repeat	257..283	CDD:275381	7/29 (24%)
		leucine-rich repeat	284..308	CDD:275381	6/24 (25%)
		leucine-rich repeat	309..336	CDD:275381	5/26 (19%)
		leucine-rich repeat	337..362	CDD:275381	6/24 (25%)
		leucine-rich repeat	363..388	CDD:275381	9/28 (32%)
		leucine-rich repeat	416..442	CDD:275381	0/25 (0%)
		AMN1	440..611	CDD:187754	33/139 (24%)
		leucine-rich repeat	443..468	CDD:275381	1/24 (4%)
		leucine-rich repeat	469..492	CDD:275381	6/22 (27%)
		leucine-rich repeat	493..519	CDD:275381	2/25 (8%)
		leucine-rich repeat	520..545	CDD:275381	10/24 (42%)
		leucine-rich repeat	546..571	CDD:275381	10/26 (38%)
		leucine-rich repeat	572..591	CDD:275381	2/5 (40%)
		leucine-rich repeat	598..619	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810