DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and amn1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001038919.1	Gene:	amn1 / 751744	ZFINID:	ZDB-GENE-060825-13	Length:	249	Species:	Danio rerio

Alignment Length:	252	Identity:	58/252 - (23%)
Similarity:	102/252 - (40%)	Gaps:	49/252 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 LTQRGDNLTHLRL--NSCKFLNASCIENVGIVCDNLIE---------LSLRNCATEPPLLNFSCL 469
            :.||.:....:|:  .|.|......:.:.|.|.|:.|.         |.|:||.     ::.|.|
Zfish    15 VAQRAEKYEDIRMLPASVKDRLLRIMTSYGTVTDSNISQLVHSGTHTLDLQNCK-----ISDSAL 74

  Fly   470 ANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLW 534
            ..:.:|        :..|.||....|         :...|:.|        ||.....|..:||.
Zfish    75 KQINSL--------HLRTILLRGCAE---------ITSEGLEV--------LAPRCPYLQVVDLT 114

  Fly   535 KAHFLSSRGLQSLAR-LHQLEELDLGWCMREASLGD-GLFQLLSNCPKLKKLFLSAVRGTTERDL 597
            ....::..|:|:||| ...||.:.|..|   ::|.| .|.:|..||..|..::.|... .|::.:
Zfish   115 GCTAVTDSGIQALARHCKCLEVISLRGC---SALSDKALLELGGNCKMLHSIYFSGTE-VTDQGV 175

  Fly   598 MHIA--ALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLL 652
            :.:|  ....:|::|.::...|:|...|..:|.||..:::.:...|..|.|:..:.|
Zfish   176 IGLATGVCSCSLKELQMVRCRNLTDLAVTAVLTNCANIRIFNFHGCPLITDKSREAL 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689
		leucine-rich repeat	393..422	CDD:275381	2/5 (40%)
		leucine-rich repeat	423..442	CDD:275381	3/20 (15%)
		LRR_RI	437..>641	CDD:238064	49/216 (23%)
		leucine-rich repeat	449..474	CDD:275381	7/33 (21%)
		leucine-rich repeat	475..499	CDD:275381	5/23 (22%)
		leucine-rich repeat	500..527	CDD:275381	4/26 (15%)
		leucine-rich repeat	528..552	CDD:275381	8/24 (33%)
		AMN1	552..>660	CDD:187754	26/104 (25%)
		leucine-rich repeat	553..580	CDD:275381	10/27 (37%)
		leucine-rich repeat	581..606	CDD:275381	4/26 (15%)
		leucine-rich repeat	607..632	CDD:275381	8/24 (33%)
		leucine-rich repeat	633..652	CDD:275381	3/18 (17%)
amn1	NP_001038919.1	AMN1	33..248	CDD:187754	54/234 (23%)
		leucine-rich repeat	59..72	CDD:275381	4/17 (24%)
		leucine-rich repeat	82..107	CDD:275381	8/41 (20%)
		leucine-rich repeat	108..133	CDD:275381	8/24 (33%)
		leucine-rich repeat	134..159	CDD:275381	10/27 (37%)
		leucine-rich repeat	160..186	CDD:275381	4/26 (15%)
		leucine-rich repeat	187..212	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900