DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and FBXL17

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_005272105.1	Gene:	FBXL17 / 64839	HGNCID:	13615	Length:	712	Species:	Homo sapiens

Alignment Length:	441	Identity:	86/441 - (19%)
Similarity:	151/441 - (34%)	Gaps:	145/441 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 PPPDAIGSTSGDG----SGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQFLADNCVDGEAA 320
            |||   .|.:.:|    :||.......|...       .|.:.||..:.|..:...:.|......
Human   260 PPP---SSPTSEGAPTEAGGDAVRAGGTAPL-------SAQQQHECGDADCRESPENPCDCHREP 314

  Fly   321 APQI-CLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLC 384
            .|:. .:..||..|||:|.|.|.|.                 ...|.|.:..| ||.
Human   315 PPETPDINQLPPSILLKIFSNLSLD-----------------ERCLSASLVCK-YWR-------- 353

  Fly   385 TLARRATMLRKLDLSWCGGFGNVSPT-EFKKFLTQRGDNLTHLRLNSCKFL--NASCIENVGIVC 446
            .|.......::||||     .....| |..:.:..|..|:..:.::.|:.:  |..|:  :...|
Human   354 DLCLDFQFWKQLDLS-----SRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCV--LAFKC 411

  Fly   447 DNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVS 511
            ..|:..:...|               |.|.         :|.::.
Human   412 PGLLRYTAYRC---------------KQLS---------DTSIIA-------------------- 432

  Fly   512 VNMDNVAAHLATYNTQLISLDLWKAHF-----LSSRGLQSL-ARLHQLEELDLGWCMREASLGDG 570
                 ||:|...         |.|.|.     |:..||:.| ::..:|:::..|.|.:.:.  :|
Human   433 -----VASHCPL---------LQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISD--EG 481

  Fly   571 LFQLLSNCPKLKKLFLSAVRGTTER----------DLMHIAALG--------------KNLEQLD 611
            :..:...|.||:::::...:..|::          :|.::..:|              :||..||
Human   482 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLD 546

  Fly   612 LMGILNITHERVYDILVNCPKLQLLDLSFCDN--IMDRDFDLLAEWSRQFK 660
            |..|..:.:|.|.:|:..|..|..|:|  |.|  |.||..:::|:..:..|
Human   547 LRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRCVEVIAKEGQNLK 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	11/45 (24%)
		leucine-rich repeat	393..422	CDD:275381	7/29 (24%)
		leucine-rich repeat	423..442	CDD:275381	3/20 (15%)
		LRR_RI	437..>641	CDD:238064	40/233 (17%)
		leucine-rich repeat	449..474	CDD:275381	2/24 (8%)
		leucine-rich repeat	475..499	CDD:275381	2/23 (9%)
		leucine-rich repeat	500..527	CDD:275381	3/26 (12%)
		leucine-rich repeat	528..552	CDD:275381	7/29 (24%)
		AMN1	552..>660	CDD:187754	29/133 (22%)
		leucine-rich repeat	553..580	CDD:275381	5/26 (19%)
		leucine-rich repeat	581..606	CDD:275381	4/48 (8%)
		leucine-rich repeat	607..632	CDD:275381	9/24 (38%)
		leucine-rich repeat	633..652	CDD:275381	8/20 (40%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	17/72 (24%)
		leucine-rich repeat	362..387	CDD:275381	7/29 (24%)
		leucine-rich repeat	388..413	CDD:275381	4/26 (15%)
		AMN1	411..573	CDD:187754	38/221 (17%)
		leucine-rich repeat	414..439	CDD:275381	8/73 (11%)
		leucine-rich repeat	440..465	CDD:275381	7/24 (29%)
		leucine-rich repeat	466..491	CDD:275381	5/26 (19%)
		leucine-rich repeat	492..517	CDD:275381	2/24 (8%)
		leucine-rich repeat	518..541	CDD:275381	2/22 (9%)
		leucine-rich repeat	542..567	CDD:275381	9/24 (38%)
		AMN1	547..>652	CDD:187754	16/51 (31%)
		leucine-rich repeat	568..593	CDD:275381	9/26 (35%)
		leucine-rich repeat	594..615	CDD:275381	1/2 (50%)
		leucine-rich repeat	619..641	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810