DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Fbxl3

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001347270.1	Gene:	Fbxl3 / 50789	MGIID:	1354702	Length:	428	Species:	Mus musculus

Alignment Length:	510	Identity:	97/510 - (19%)
Similarity:	167/510 - (32%)	Gaps:	185/510 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 RIWAYGLTKNWT------CLWEATESDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYY 225
            |..|..:.:||.      .||...|.:|::|        |.|..|.|           |..
Mouse    56 RAHASQVCRNWNQVFHMPDLWRCFEFELNQP--------ATSYLKAT-----------HPE---- 97

  Fly   226 TEIDAIMLCGRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNC 290
                               |.||.|.:|                        |:.|:.:.|:.:.
Mouse    98 -------------------LIKQIIKRH------------------------SNHLQYVSFKVDS 119

  Fly   291 GEDGATKLHEFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRT 355
            .::.|    |...:.|||.:  ||                           .||:|..:.....:
Mouse   120 SKESA----EAACDILSQLV--NC---------------------------SLKTLGLISTARPS 151

  Fly   356 FYDISRHPLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRG 420
            |.|:.:...:.|...:     ..:|:.|.:|        |:|.:      .|.....|..:....
Mouse   152 FMDLPKSHFISALTVV-----FVNSKSLSSL--------KIDDT------PVDDPSLKVLVANNS 197

  Fly   421 DNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYF 485
            |.|..|:::||..::.:.|..|...|..|.||:          ||:..|::
Mouse   198 DTLKLLKMSSCPHVSPAGILCVADQCHGLRELA----------LNYHLLSD-------------- 238

  Fly   486 ETELLLSM-LEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLAR 549
              ||||:: .|.:.:|:||.:         |.|:.:....:...|....|.|....|..:..:..
Mouse   239 --ELLLALSSEKHVRLEHLRI---------DVVSENPGQTHFHTIQKSSWDAFIKHSPKVNLVMY 292

  Fly   550 LHQLEE--------------LDLGWCMREASLGDGLFQLLSNCPKLKKLFLSA--VRGTTERDLM 598
            ....||              |..|..:.:..||    ::...||:|.:|.:.|  :|...| :|:
Mouse   293 FFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLG----RVGMTCPRLVELVVCANGLRPLDE-ELI 352

  Fly   599 HIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIM--DRDFDL 651
            .||...|||..:.| |...::.....:.:..|.. :|..||..:.::  |:.:.|
Mouse   353 RIAERCKNLSAIGL-GECEVSCSAFVEFVKMCGG-RLSQLSIMEEVLIPDQKYSL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	6/45 (13%)
		leucine-rich repeat	393..422	CDD:275381	4/28 (14%)
		leucine-rich repeat	423..442	CDD:275381	5/18 (28%)
		LRR_RI	437..>641	CDD:238064	48/220 (22%)
		leucine-rich repeat	449..474	CDD:275381	6/24 (25%)
		leucine-rich repeat	475..499	CDD:275381	5/24 (21%)
		leucine-rich repeat	500..527	CDD:275381	5/26 (19%)
		leucine-rich repeat	528..552	CDD:275381	4/23 (17%)
		AMN1	552..>660	CDD:187754	27/118 (23%)
		leucine-rich repeat	553..580	CDD:275381	7/40 (18%)
		leucine-rich repeat	581..606	CDD:275381	8/26 (31%)
		leucine-rich repeat	607..632	CDD:275381	4/24 (17%)
		leucine-rich repeat	633..652	CDD:275381	5/21 (24%)
Fbxl3	NP_001347270.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		F-box-like	36..77	CDD:315592	5/20 (25%)
		LRR 1	119..146		10/59 (17%)
		leucine-rich repeat	174..199	CDD:275381	6/38 (16%)
		LRR 2	181..207		5/31 (16%)
		leucine-rich repeat	200..225	CDD:275381	7/24 (29%)
		LRR 3	208..233		8/34 (24%)
		LRR 4	234..259		9/49 (18%)
		leucine-rich repeat	252..286	CDD:275381	9/42 (21%)
		leucine-rich repeat	287..333	CDD:275381	7/49 (14%)
		LRR 5	316..341		7/28 (25%)
		leucine-rich repeat	334..360	CDD:275381	8/26 (31%)
		LRR 6	343..368		9/26 (35%)
		leucine-rich repeat	361..383	CDD:275381	3/22 (14%)
		LRR 7	369..394		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900