DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and fbxl4

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001007316.1	Gene:	fbxl4 / 492349	ZFINID:	ZDB-GENE-041114-187	Length:	607	Species:	Danio rerio

Alignment Length:	616	Identity:	210/616 - (34%)
Similarity:	313/616 - (50%)	Gaps:	64/616 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LEQYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPETFPMRTYGDWWQRAPSATREIQ 128
            :|||...:|||||.||.:.|:|||..|:.|.|..:|:.||:.:|...||||.||::..|:|...:
Zfish    40 VEQYGKEILDFSSHYGSENSMSYTMWNLAGVPNVYPSSGDFTQTAVFRTYGTWWEQCISSTPRFR 104

  Fly   129 PQNLPKLETHDYVVVYFEEFVVPTEVAIFETFNPGAVVRIWAYGLTK---------NWTCLWEAT 184
             :..|...:.||:.:.|||.|.||.|.:.||::|||:|:|.|..|..         .|..||...
Zfish   105 -RTPPSFHSQDYLELAFEEPVYPTAVEVLETYHPGAIVKIMACSLNPFSQNPPTDVRWEVLWSGK 168

  Fly   185 ESDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQ 249
            .:....|   .:|:|:|::|:.:..|..||::.|.|.|:||||:||::|.|   .:.:.:||..:
Zfish   169 PNKALTP---QARQFSPNIKQISFTTNLLRLEVNSSLLDYYTELDAVILRG---VRERPILALYK 227

  Fly   250 ITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQFLADNC 314
            |.......:|...:.|....|                  .|....|         :..|.||:..
Zfish   228 IPVIDINDLSDSEEEISEAGG------------------LCCRSTA---------ENRQSLANGY 265

  Fly   315 VDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVAS 379
            .|           .||:|::..|:|:|.:..|.|:....:.|:.....||.|.::||:|||...:
Zfish   266 FD-----------RLPYELIQLIVSHLPVPDLCRLAQSCKLFHKHCCDPLQYIQLSLQPYWARLT 319

  Fly   380 SELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGI 444
            ...||.|..|.|:|::|:|||.|..|.|:|..|..|:...|.:|..|.::.|.||..:|:|.:..
Zfish   320 DASLCHLQSRCTLLQRLNLSWTGNRGAVTPAGFCSFMKACGASLVCLEVSCCHFLTEACLEVITQ 384

  Fly   445 VCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCG 509
            .|..|.||:|.:|....|.. |:.:|.|.:|.||.|::|..|...:||:|....:|:||||..|.
Zfish   385 TCPCLQELNLASCDRLQPQA-FNHIAKLTHLRRLVLYRTKVEQSAILSILTFCPELRHLNLGSCV 448

  Fly   510 VSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSL---ARLHQLEELDLGWCMREASLGDGL 571
            :..:.|.|.:.|:.....|.|||||:...||.|||..|   .||  |||||||||....|.....
Zfish   449 MIEDYDVVVSMLSARCRSLRSLDLWRCRNLSERGLAELVSGCRL--LEELDLGWCSTLQSSSACF 511

  Fly   572 FQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLL 636
            ..|..:.|:|:||||:|.|...:.||..:||....|:.||::|...::...:..:|..||:|:||
Zfish   512 QHLARSLPRLRKLFLTANRTVCDADLEELAANCSALQHLDILGTRMVSSASLRKLLQCCPRLKLL 576

  Fly   637 DLSFCDNIMDRDFDLLAEWSRQF-KVDIKSS 666
            |:|||..|   |...:.|.:..| .|.||.|
Zfish   577 DVSFCSQI---DSRFVQELNGLFPNVSIKKS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	13/45 (29%)
		leucine-rich repeat	393..422	CDD:275381	12/28 (43%)
		leucine-rich repeat	423..442	CDD:275381	7/18 (39%)
		LRR_RI	437..>641	CDD:238064	79/206 (38%)
		leucine-rich repeat	449..474	CDD:275381	9/24 (38%)
		leucine-rich repeat	475..499	CDD:275381	9/23 (39%)
		leucine-rich repeat	500..527	CDD:275381	9/26 (35%)
		leucine-rich repeat	528..552	CDD:275381	14/26 (54%)
		AMN1	552..>660	CDD:187754	41/108 (38%)
		leucine-rich repeat	553..580	CDD:275381	11/26 (42%)
		leucine-rich repeat	581..606	CDD:275381	11/24 (46%)
		leucine-rich repeat	607..632	CDD:275381	6/24 (25%)
		leucine-rich repeat	633..652	CDD:275381	9/18 (50%)
fbxl4	NP_001007316.1	F-box-like	266..312	CDD:289689	14/56 (25%)
		leucine-rich repeat	281..303	CDD:275381	4/21 (19%)
		leucine-rich repeat	304..326	CDD:275381	9/21 (43%)
		AMN1	<317..436	CDD:187754	43/119 (36%)
		leucine-rich repeat	333..362	CDD:275381	12/28 (43%)
		leucine-rich repeat	363..388	CDD:275381	8/24 (33%)
		leucine-rich repeat	389..413	CDD:275381	9/24 (38%)
		AMN1	414..591	CDD:187754	71/181 (39%)
		leucine-rich repeat	414..438	CDD:275381	9/23 (39%)
		leucine-rich repeat	439..466	CDD:275381	9/26 (35%)
		leucine-rich repeat	467..492	CDD:275381	12/24 (50%)
		leucine-rich repeat	493..520	CDD:275381	11/26 (42%)
		leucine-rich repeat	521..545	CDD:275381	11/23 (48%)
		leucine-rich repeat	547..572	CDD:275381	6/24 (25%)
		leucine-rich repeat	573..598	CDD:275381	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586794
Domainoid	1	1.000	135	1.000	Domainoid score	I4939
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8128
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2586
OMA	1	1.010	-	-		QHG50183
OrthoDB	1	1.010	-	-		D298796at33208
OrthoFinder	1	1.000	-	-		FOG0003673
OrthoInspector	1	1.000	-	-		oto41004
orthoMCL	1	0.900	-	-		OOG6_108781
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5732
SonicParanoid	1	1.000	-	-		X7198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800