DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and FipoQ

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_733291.1	Gene:	FipoQ / 43475	FlyBaseID:	FBgn0039667	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	108/471 - (22%)
Similarity:	157/471 - (33%)	Gaps:	168/471 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 DGEAAAP--QICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPY---W 375
            ||...:|  ...:..||.::||.|.|||..:.:.|:..:.|.:..|:....|:..:||:|.   .
  Fly    22 DGTVRSPFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLRPEVSGL 86

  Fly   376 DVASSELLCTL--ARRATMLRKLDLSWCGGFGNVSPTEFKKF-----LTQRGDNLTHLRLN---- 429
            .|.|.|:|..|  .|....||.::|          |.|....     |:.:..||||:.|:
  Fly    87 HVGSLEMLLQLISVRFGPTLRYIEL----------PIELITHTVLHELSAKCPNLTHMLLDFSTA 141

  Fly   430 ------------------SC-----------------KFLNA-----------SCIE-------- 440
                              .|                 .|:|.           .|.|
  Fly   142 MQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEV 206

  Fly   441 -------------------NVGIVCDNLIELSLRNC-ATEPPLLNF------------------- 466
                               .:..:.|:.|:....|| ..|...:||
  Fly   207 INVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRL 271

  Fly   467 SCL----ANLKN------------LERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVN-- 513
            :||    .:||:            |:.||:..|...||.|:.||.....||.|:..    .:|
  Fly   272 TCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAG----QINGF 332

  Fly   514 MDNVAAHLATYNT--QLISLDLWKAHFLSSRGLQSLARL--HQLEELDL-GWCMREASLGDGLFQ 573
            .|:|........|  .||||||..:..:|..||....:.  |||....| |.......|...:..
  Fly   333 NDSVLKQWMESGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILP 397

  Fly   574 LLSNCPKLKKLFLSAVRGTTER--------DLMH-IAALGKNLEQLDLMG-----ILNITHERVY 624
            ||.||..:       |.||.|:        .||. ||:...|||:|:|..     ..:...::..
  Fly   398 LLGNCKII-------VMGTAEKLGVNIHVDQLMDTIASNCGNLERLELRWDPDNLRFSDKSQKAI 455

  Fly   625 DIL-VNCPKLQLLDLS 639
            ||| |.|.||:.:.||
  Fly   456 DILRVKCLKLRCMVLS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	13/45 (29%)
		leucine-rich repeat	393..422	CDD:275381	6/33 (18%)
		leucine-rich repeat	423..442	CDD:275381	9/95 (9%)
		LRR_RI	437..>641	CDD:238064	70/288 (24%)
		leucine-rich repeat	449..474	CDD:275381	9/48 (19%)
		leucine-rich repeat	475..499	CDD:275381	9/23 (39%)
		leucine-rich repeat	500..527	CDD:275381	7/30 (23%)
		leucine-rich repeat	528..552	CDD:275381	9/25 (36%)
		AMN1	552..>660	CDD:187754	31/104 (30%)
		leucine-rich repeat	553..580	CDD:275381	8/27 (30%)
		leucine-rich repeat	581..606	CDD:275381	8/33 (24%)
		leucine-rich repeat	607..632	CDD:275381	9/30 (30%)
		leucine-rich repeat	633..652	CDD:275381	3/7 (43%)
FipoQ	NP_733291.1	F-box-like	34..80	CDD:289689	13/45 (29%)
		leucine-rich repeat	131..156	CDD:275381	4/24 (17%)
		leucine-rich repeat	157..175	CDD:275381	1/17 (6%)
		leucine-rich repeat	219..244	CDD:275381	4/24 (17%)
		leucine-rich repeat	245..270	CDD:275381	3/24 (13%)
		leucine-rich repeat	271..295	CDD:275381	4/23 (17%)
		leucine-rich repeat	296..320	CDD:275381	9/23 (39%)
		leucine-rich repeat	321..348	CDD:275381	7/30 (23%)
		leucine-rich repeat	349..375	CDD:275381	9/25 (36%)
		leucine-rich repeat	376..403	CDD:275381	7/26 (27%)
		leucine-rich repeat	405..432	CDD:275381	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830